CD4+和CD8+调节性T细胞在自身免疫中的不同功能

IF 27.7 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2025-01-27 DOI:10.1038/s41590-024-02071-w

Ziyang Xu, Bing Su

引用次数: 0

摘要

Chen等人利用一种新的人类扁桃体免疫类器官系统证明，通过控制自身反应性体液和细胞反应，人类CD4+调节性T细胞（Treg细胞）和CD8+ Treg细胞协同抑制其他不受控制的自身免疫性疾病进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Distinct functions of CD4+ and CD8+ regulatory T cells in autoimmunity

查看原文本刊更多论文

Distinct functions of CD4+ and CD8+ regulatory T cells in autoimmunity

Using a novel human tonsil immune organoid system, Chen et al. demonstrate that by controlling autoreactive humoral and cellular responses, human CD4+ regulatory T cells (Treg cells) and CD8+ Treg cells cooperatively restrain the otherwise uncontrolled autoimmune disease progression.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.