索非布韦：一个全面的概况。

Q1 Pharmacology, Toxicology and Pharmaceutics

Profiles of drug substances, excipients, and related methodology Pub Date : 2025-01-01 Epub Date: 2025-01-09 DOI:10.1016/bs.podrm.2024.10.003

Jude Majed Lababidi, Mohamed Fawzy Kabil, Hassan Mohamed El-Said Azzazy

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引用次数: 0

摘要

索非布韦是一种核苷酸类似物，是一种抗病毒药物，属于直接作用抗病毒药物（DAAs）。它主要用于治疗慢性丙型肝炎病毒（HCV）感染。索非布韦通过抑制丙型肝炎病毒的复制，破坏其产生RNA的能力并有效减少体内的病毒载量来起作用。本章提供了索非布韦的全面检查，包括其命名法，理化性质，合成和热分析。此外，它提出了各种分析方法，用于分光光度法和色谱法评估索非布韦在不同的基质。

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Sofosbuvir: A comprehensive profile.

Sofosbuvir, a nucleotide analogue, is an antiviral medication that belongs to the class of direct-acting antivirals (DAAs). It is primarily used in the treatment of chronic hepatitis C virus (HCV) infections. Sofosbuvir works by inhibiting the replication of HCV, disrupting its ability to produce RNA and effectively reducing the viral load in the body. This chapter offers a comprehensive examination of sofosbuvir, including its nomenclature, physiochemical attributes, synthesis, and thermal analysis. Furthermore, it presents various analytical methods employed for both spectrophotometric and chromatographic assessments of sofosbuvir in different matrices.

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来源期刊

Profiles of drug substances, excipients, and related methodology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

13.10

自引率

0.00%

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