多巴胺二聚体的有效合成。

IF 1.9 4区医学 Q3 CHEMISTRY, MEDICINAL

Medicinal Chemistry Pub Date : 2025-01-23 DOI:10.2174/0115734064262975241208063806

Zhou Dejun, Zhang Yuying, Liu Xiaoyue, Zheng Huachuan

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引用次数: 0

摘要

背景：多巴胺(1)是一种常用的血管加压剂，主要用于治疗各种类型的休克、充血性心力衰竭和急性肾功能衰竭。多巴胺二聚体(2)是多巴胺原料生产过程中或多巴胺药物本身代谢过程中产生的杂质。方法：本文提出了一种由3,4-二甲氧基苯乙酸甲酯(4)和3,4-二甲氧基苯乙基胺(5)缩合、还原、去甲基化合成多巴胺二聚体的有效方法。结果：以易获得的原料为原料，经过5步合成，总收率为48%。结论：该合成方法简便，便于制药企业采用和实施。

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Effective Synthesis of Dopamine Dimer.

Background: Dopamine (1) is a commonly used vasopressor, primarily employed to treat various types of shock, congestive heart failure, and acute renal failure. Dopamine dimer (2) is an impurity generated during the production process of dopamine raw materials or the metabolism of dopamine drugs themselves.

Methods: This article presents an effective method for synthesizing dopamine dimer through the condensation of methyl 3,4-dimethoxyphenyl acetate (4) and 3,4-dimethoxyphenylethyl amine (5), followed by reduction and demethylation.

Results: The product was synthesized from easily accessible raw materials, achieving a total yield of 48% over five steps.

Conclusion: This synthesis method is simple and beneficial for pharmaceutical companies to adopt and implement.

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来源期刊

Medicinal Chemistry 医学-医药化学

CiteScore

4.30

自引率

4.30%

发文量

109

审稿时长

12 months

期刊介绍： Aims & Scope Medicinal Chemistry a peer-reviewed journal, aims to cover all the latest outstanding developments in medicinal chemistry and rational drug design. The journal publishes original research, mini-review articles and guest edited thematic issues covering recent research and developments in the field. Articles are published rapidly by taking full advantage of Internet technology for both the submission and peer review of manuscripts. Medicinal Chemistry is an essential journal for all involved in drug design and discovery.