振兴心脏：心肌梗死后心肌细胞再生的策略和工具。

IF 6.4 1区医学 Q1 CELL & TISSUE ENGINEERING

npj Regenerative Medicine Pub Date : 2025-01-22 DOI:10.1038/s41536-025-00394-2

Axelle Bois, Catarina Grandela, James Gallant, Christine Mummery, Philippe Menasché

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引用次数: 0

摘要

心肌梗死（MI）导致数百万心肌细胞的损失，目前的治疗并不能解决这一根本问题。受低等脊椎动物和新生小鼠再生能力的启发，新的治疗方法集中在刺激成人心脏的心肌细胞分裂。这篇综述探讨了心脏再生的策略，提供了对心肌细胞增殖的见解，评估了体内模型，并讨论了整合体外人类心脏模型来推进心脏再生研究。

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Revitalizing the heart: strategies and tools for cardiomyocyte regeneration post-myocardial infarction.

Myocardial infarction (MI) causes the loss of millions of cardiomyocytes, and current treatments do not address this root issue. New therapies focus on stimulating cardiomyocyte division in the adult heart, inspired by the regenerative capacities of lower vertebrates and neonatal mice. This review explores strategies for heart regeneration, offers insights into cardiomyocyte proliferation, evaluates in vivo models, and discusses integrating in vitro human cardiac models to advance cardiac regeneration research.

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来源期刊

npj Regenerative Medicine Engineering-Biomedical Engineering

CiteScore

10.00

自引率

1.40%

发文量

审稿时长

12 weeks

期刊介绍： Regenerative Medicine, an innovative online-only journal, aims to advance research in the field of repairing and regenerating damaged tissues and organs within the human body. As a part of the prestigious Nature Partner Journals series and in partnership with ARMI, this high-quality, open access journal serves as a platform for scientists to explore effective therapies that harness the body's natural regenerative capabilities. With a focus on understanding the fundamental mechanisms of tissue damage and regeneration, npj Regenerative Medicine actively encourages studies that bridge the gap between basic research and clinical tissue repair strategies.