回顾性描述性报告，比较获取系统以改进大鼠静脉自我给药。

IF 1.3 4区农林科学 Q2 VETERINARY SCIENCES

Laboratory Animals Pub Date : 2025-06-01 Epub Date: 2025-01-23 DOI:10.1177/00236772241297777

José G Lozeman-van 't Klooster, Heidi Mb Lesscher

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引用次数: 0

摘要

对于手术自我给药，永久静脉插管需要保持开放和操作数月，无感染或阻塞。在这里，我们回顾性地报告了我们在三项研究中使用不同接入系统的经验和观察结果。我们确定了一种改进的颈静脉插管方法，这对动物、生物技术人员和研究人员来说是一个巨大的进步。一个封闭的、膜密封的系统，在后支架上装有一个磁铁，使用方便，允许快速（断开）连接，导致不超过10%的动物轻微刺激和表面感染（柔软的贴片），防止堵塞（封闭系统），并允许社会住房（金属帽）。

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Retrospective descriptive report comparing access systems to refine intravenous self-administration in rats.

For operant self-administration, permanent intravenous cannulas need to remain open and operational for months without infections or blockages. Here, we report retrospectively on our experiences and observations using different access systems during three studies. We identified a refined method for vena jugularis cannulation that is a vast improvement for the animals, biotechnicians and researchers. A closed and membrane-sealed system equipped with a magnet in the backmount was easy to use, allowed quick (dis)connection, caused no more than 10% of the animals a little irritation and superficial infection (softer patch), prevented clogging (closed system) and allowed for social housing (metal cap).

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来源期刊

Laboratory Animals 生物-动物学

CiteScore

4.90

自引率

8.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The international journal of laboratory animal science and welfare, Laboratory Animals publishes peer-reviewed original papers and reviews on all aspects of the use of animals in biomedical research. The journal promotes improvements in the welfare or well-being of the animals used, it particularly focuses on research that reduces the number of animals used or which replaces animal models with in vitro alternatives.