姜黄素在胃癌治疗中的作用机制及未来发展方向。

IF 2.5 4区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

World Journal of Gastrointestinal Oncology Pub Date : 2025-01-15 DOI:10.4251/wjgo.v17.i1.100369

Xin-Yue Wei, Wen-Bo Cao, Sai-Jun Mo, Zhi-Yan Sun

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引用次数: 0

摘要

Yang等人的研究全面探讨了姜黄素对胃癌（GC）的治疗潜力。利用网络药理学，研究人员确定了48个姜黄素相关基因，其中31个与GC靶点重叠。关键基因，包括ESR1、EGFR、CYP3A4、MAPK14、CYP1A2和CYP2B6，与GC患者的低生存率相关。分子对接证实姜黄素与这些基因有较强的结合亲和力。体外实验表明，姜黄素可有效抑制BGC-823的生长和增殖，提示其在GC中的治疗潜力可通过多靶点和多途径实现。

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Curcumin in gastric cancer treatment: A commentary on mechanistic insights and future directions.

The study by Yang et al presents a comprehensive investigation into the therapeutic potential of curcumin for gastric cancer (GC). Using network pharmacology, the researchers identified 48 curcumin-related genes, 31 of which overlap with GC targets. Key genes, including ESR1, EGFR, CYP3A4, MAPK14, CYP1A2, and CYP2B6, are linked to poor survival in GC patients. Molecular docking confirmed strong binding affinity of curcumin to these genes. In vitro experiments demonstrated that curcumin effectively inhibits the growth and proliferation of BGC-823, suggesting its therapeutic potential in GC through multiple targets and pathways.

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来源期刊

World Journal of Gastrointestinal Oncology Medicine-Gastroenterology

CiteScore

4.20

自引率

3.30%

发文量

1082

期刊介绍： The World Journal of Gastrointestinal Oncology (WJGO) is a leading academic journal devoted to reporting the latest, cutting-edge research progress and findings of basic research and clinical practice in the field of gastrointestinal oncology.