重新审视血红蛋白:用世界上第一个用于渔业研究的分子遗传标记描绘种群结构。

IF 2.9 3区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Royal Society Open Science Pub Date : 2025-01-15 eCollection Date: 2025-01-01 DOI:10.1098/rsos.241760
Bjørghild Breistein, Geir Dahle, Torild Johansen, Per Erik Jorde, Kevin A Glover
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引用次数: 0

摘要

当血红蛋白基因分型在20世纪60年代初用于调查大西洋鳕鱼(Gadus morhua)的种群遗传结构时,它成为世界范围内渔业研究中首批部署的分子遗传标记之一。然而,由于其潜在的选择潜力,其适用性受到质疑。虽然中立性问题关注的是第一批群体遗传学家,但选择下的标记现在通常用于研究群体遗传结构。在这里,我们在5年后重新研究了血红蛋白基因分型,分析了挪威大约2500公里海岸线上73个产卵地点的6000条成熟大西洋鳕鱼。等位基因频率呈纬度梯度,HbI-2等位基因向南减少。我们观测到的HbI-2频率始终略低于20世纪60年代的数据,这可能反映了对海洋温度升高的适应性变化。然而,尽管存在这种差异,在这里和在历史研究中观察到的等位基因频率的南北模式重叠,与目前对该物种群体遗传结构的了解一致。因此,我们得出结论,这个曾经受到质疑的标记,首次提供了对大西洋鳕鱼遗传结构的分子遗传学见解,提供了与该地区数十年对该物种的研究所揭示的距离隔离模式一致的知识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Haemoglobin revisited: delineating population structure with the world's first molecular genetic marker used in fisheries research.

When haemoglobin genotyping was implemented in the early 1960s to investigate population genetic structure in Atlantic cod (Gadus morhua), it became one of the first molecular genetic markers deployed in fisheries research worldwide. However, its suitability was questioned due to its potential for selection. While the issue of neutrality concerned the first population geneticists, markers under selection are now routinely used to study population genetic structure. Here, we revisited haemoglobin genotyping half a decade later to analyse >6000 mature Atlantic cod from 73 spawning locations throughout Norway's approximately 2500 km coastline. A latitudinal gradient in allele frequencies, with a decrease in the HbI-2 allele towards the south, was observed. Our observed HbI-2 frequencies were consistently slightly lower than data from the 1960s, potentially reflecting adaptive changes to increasing sea temperatures. However, despite this difference, the observed north-south pattern in allele frequencies observed here and in the historical studies overlapped, aligning with current knowledge of population genetic structure in this species. We therefore conclude that this once questioned marker, which provided the first molecular genetic insights into genetic structure in Atlantic cod, provides knowledge consistent with the isolation by distance pattern revealed through decades of research in this species in this region.

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来源期刊
Royal Society Open Science
Royal Society Open Science Multidisciplinary-Multidisciplinary
CiteScore
6.00
自引率
0.00%
发文量
508
审稿时长
14 weeks
期刊介绍: Royal Society Open Science is a new open journal publishing high-quality original research across the entire range of science on the basis of objective peer-review. The journal covers the entire range of science and mathematics and will allow the Society to publish all the high-quality work it receives without the usual restrictions on scope, length or impact.
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