KLF15在小鼠小脑中的分布及功能意义。

IF 3.3 3区医学 Q2 NEUROSCIENCES

Molecular Brain Pub Date : 2025-01-21 DOI:10.1186/s13041-025-01172-3

Dan Li, Shuijing Cao, Yanrong Chen, Yueyan Liu, Kugeng Huo, Zhuangqi Shi, Shuxin Han, Liecheng Wang

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引用次数: 0

摘要

kruppel样因子15 （KLF15）是KLF家族的一员，密切参与许多生物过程。然而，KLF15调控神经发育的机制尚不清楚。考虑到神经网络发育的复杂性和重要性，在本研究中，我们研究了KLF15在神经网络发育中的强大调节作用。KLF15在小脑中高表达，在浦肯野细胞中富集，在神经发育的15 - 20天，KLF15的表达显著增加。KLF15的敲低导致小鼠浦肯野细胞的丧失和运动能力受损。因此，我们的研究旨在阐明KLF15与小鼠浦肯野细胞之间的关系，可能为小鼠小脑发育机制提供新的研究思路。

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Distribution and functional significance of KLF15 in mouse cerebellum.

Kruppel-like factor 15 (KLF15), a member of the KLF family, is closely involved in many biological processes. However, the mechanism by which KLF15 regulates neural development is still unclear. Considering the complexity and importance of neural network development, in this study, we investigated the potent regulatory role of KLF15 in neural network development. KLF15 was detected highly expressed in the cerebellum and enriched in Purkinje cells, with a significant increase in KLF15 expression between 15 and 20 days of neural development. Knockdown of KLF15 led to loss of Purkinje cells and impaired motility in mice. Therefore, our study aims to elucidate the relationship between KLF15 and Purkinje cells in mice, may provide a new research idea for the developmental mechanism of the mouse cerebellum.

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来源期刊

Molecular Brain NEUROSCIENCES-

CiteScore

7.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Molecular Brain is an open access, peer-reviewed journal that considers manuscripts on all aspects of studies on the nervous system at the molecular, cellular, and systems level providing a forum for scientists to communicate their findings. Molecular brain research is a rapidly expanding research field in which integrative approaches at the genetic, molecular, cellular and synaptic levels yield key information about the physiological and pathological brain. These studies involve the use of a wide range of modern techniques in molecular biology, genomics, proteomics, imaging and electrophysiology.