miR-21单核苷酸多态性与非小细胞肺癌易感性的相关性

IF 1.5 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiothoracic Surgery Pub Date : 2025-01-20 DOI:10.1186/s13019-024-03322-5

Miao Zhang, Ming Zhang, Ruixue Han, Xin Yu, Zhaolu Song

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引用次数: 0

摘要

背景：非小细胞肺癌（NSCLC）等疾病中miRNA及其snp的研究仍存在空白。该研究旨在通过研究miR-21及其snp与NSCLC易感性之间的关系，为NSCLC的治疗提供有用的信息。方法：采集非小细胞肺癌（NSCLC）患者（205例）和无癌对照组（217例）的血清进行RNA提取。采用qRT-PCR检测miR-21的表达，采用Taqman qPCR对miR-21 snp （rs1292037, rs6504593）进行基因分型和定量。本研究采用logistic回归分析miR-21表达、miR-21 snp及其相互作用与NSCLC患者易感性的关系。结果：本研究显示miR-21过表达与NSCLC相关。rs1292037和rs6504593的C等位基因和CC基因型与NSCLC易感风险增加相关。此外，rs1292037和rs6504593的相互作用也是NSCLC的危险因素。rs1292037和rs6504593的CC基因型与miR-21表达升高相关。结论：miR-21、miR-21 snp rs1292037和rs6504593的过表达及其相互作用与NSCLC易感性相关。MiR-21及其snp具有成为非小细胞肺癌治疗靶点的潜力。本研究为非小细胞肺癌的治疗提供了重要信息。

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The correlation between miR-21 single nucleotide polymorphisms and the susceptibility of non-small cell lung cancer.

Background: There are still gaps in the study of the miRNA and its SNPs in some diseases such as non-small cell lung cancer (NSCLC). The study aimed to provide useful information on the treatment of NSCLC by investigating the association between miR-21 and its SNPs and NSCLC susceptibility.

Methods: The serum of NSCLC patients (n = 205) and cancer-free controls (n = 217) were collected in this study for RNA extraction. The qRT-PCR was used to evaluate the expression of miR-21 and Taqman qPCR was used for genotyping and quantifying miR-21 SNPs (rs1292037, rs6504593). The association of the expression of miR-21, the miR-21 SNPs and their interactions with the susceptibility of NSCLC patients were analysed using logistic regression analysis in this study.

Results: This study showed that the overexpression of miR-21 was related to NSCLC. The C allele and CC genotypes of rs1292037 and rs6504593 were associated with the increased risk of NSCLC susceptibility. Moreover, the interactions of rs1292037 and rs6504593 were also a risk factor for NSCLC. The CC genotypes of rs1292037 and rs6504593 were associated with the increase of miR-21 expression.

Conclusion: The overexpression of miR-21, the miR-21 SNPs rs1292037 and rs6504593 and their interactions were associated with NSCLC susceptibility. MiR-21 and its SNPs have potential for being targets in the therapy of NSCLC. This study provided important information for the treatment of NSCLC.

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来源期刊

Journal of Cardiothoracic Surgery 医学-心血管系统

CiteScore

2.50

自引率

6.20%

发文量

286

审稿时长

4-8 weeks

期刊介绍： Journal of Cardiothoracic Surgery is an open access journal that encompasses all aspects of research in the field of Cardiology, and Cardiothoracic and Vascular Surgery. The journal publishes original scientific research documenting clinical and experimental advances in cardiac, vascular and thoracic surgery, and related fields. Topics of interest include surgical techniques, survival rates, surgical complications and their outcomes; along with basic sciences, pediatric conditions, transplantations and clinical trials. Journal of Cardiothoracic Surgery is of interest to cardiothoracic and vascular surgeons, cardiothoracic anaesthesiologists, cardiologists, chest physicians, and allied health professionals.