Benralizumab成功治疗危及生命的哮喘加重1例

IF 1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Internal Medicine Pub Date : 2025-01-15 DOI:10.2169/internalmedicine.4737-24

Suzuka Matsuoka, Kenichiro Kudo, Mayu Goda, Tomoyoshi Inoue, Toki Kitano, Yuto Sasano, Keiichi Fujiwara

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引用次数: 0

摘要

一名52岁日本男性，有儿童哮喘病史，以进行性呼吸困难就诊于急诊科。尽管皮下注射肾上腺素、沙丁胺醇雾化和静脉注射甲基强的松龙，二氧化碳分压（pCO2）仍升高到110 mmHg。患者因严重呼吸衰竭而插管，并开始机械通气。尽管进行了适当的治疗，严重的支气管痉挛仍经常发生。因此，我们决定使用生物制剂。给予单剂量贝纳利珠单抗后，患者呼吸状况改善，pCO2、潮气量和气道阻力恢复正常。我们在给予贝纳利珠单抗两天后成功拔管。

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Case of Life-threating Asthma Exacerbation Successfully Treated with Benralizumab.

A 52-year-old Japanese man with a history of childhood asthma presented at our emergency department with progressive dyspnea. Despite subcutaneous adrenaline injections, salbutamol nebulization, and intravenous methylprednisolone, the carbon dioxide partial pressure (pCO₂) increased to 110 mmHg. The patient was intubated, and mechanical ventilation was initiated because of severe respiratory failure. Severe bronchospasm frequently occurs despite appropriate treatment. Therefore, we decided to administer biologics. After the administration of a single dose of benralizumab, his respiratory condition improved, with normalization of pCO₂, tidal volume, and airway resistance. We successfully extubated the patient two days after the administration of benralizumab.

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来源期刊

Internal Medicine 医学-医学：内科

CiteScore

1.90

自引率

8.30%

发文量

审稿时长

2.2 months

期刊介绍： Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine. Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.