跨机构和跨学科合作在定义和执行定量系统药理学策略中的作用。

Q1 Pharmacology, Toxicology and Pharmaceutics

Handbook of experimental pharmacology Pub Date : 2025-01-21 DOI:10.1007/164_2024_736

Paolo Vicini, Piet H van der Graaf

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引用次数: 0

摘要

定量系统药理学（QSP）的应用使治疗发现和开发的许多领域取得了实质性进展和影响。这项新技术越来越被工业界、学术界和解决方案提供商所接受，并受到监管机构的更大关注。在本章中，我们总结了机构和学科之间的有效合作如何支持QSP的发展并扩大其应用领域的关键方面。我们通过选择成功的跨机构或跨职能合作来举例说明这些考虑，这些合作导致了QSP建模结果或基础设施的重用、重新利用或扩展，并产生了重要的和新颖的结果。

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The Role of Cross-Institutional and Interdisciplinary Collaboration in Defining and Executing a Quantitative Systems Pharmacology Strategy.

The application of quantitative systems pharmacology (QSP) has enabled substantial progress and impact in many areas of therapeutic discovery and development. This new technology is increasingly accepted by industry, academia, and solution providers, and is enjoying greater interest from regulators. In this chapter, we summarize key aspects regarding how effective collaboration among institutions and disciplines can support the growth of QSP and expand its application domain. We exemplify these considerations through a selection of successful cross-institutional or cross-functional collaborations, which resulted in reuse, repurposing, or extension of QSP modeling results or infrastructure, with important and novel results.

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来源期刊

Handbook of experimental pharmacology Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

5.20

自引率

0.00%

发文量

期刊介绍： The Handbook of Experimental Pharmacology is one of the most authoritative and influential book series in pharmacology. It provides critical and comprehensive discussions of the most significant areas of pharmacological research, written by leading international authorities. Each volume in the series represents the most informative and contemporary account of its subject available, making it an unrivalled reference source.