选择性荧光介导的杂环分子合成研究进展。

IF 7 2区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Chemical record Pub Date : 2025-01-16 DOI:10.1002/tcr.202400216

Sukanya Das, Risika Das, Tapas Ghosh, Raj Kumar Nandi

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引用次数: 0

摘要

Selectfluor[1-氯甲基-4-氟-1,4-重氮双环[2.2.2]辛烷双（四氟硼酸盐）]是当代化学中一种非常有价值的试剂，它不仅是一种亲电氟化剂，而且是合成各种药学上相关杂环的有效催化剂。这篇综述文章试图提出一个全面的概述，重要的杂环形成促进了选择性氟。本文主要综述了近8年来（2017- 2024年4月）无金属和金属催化的选择性氟介导环化过程的最新进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Recent Advancement on Selectfluor Mediated Synthesis of Heterocyclic Molecules.

Selectfluor, [1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)], is a highly valuable reagent in contemporary chemistry, serving not only as an electrophilic fluorinating agent but also as an effective catalyst in the synthesis of various pharmaceutically relevant heterocycles. This review article seeks to present a comprehensive overview of the significant heterocyclic ring formations facilitated by selectfluor. Both metal-free and metal-catalyzed recent advancement on selectfluor mediated cyclisation processes are discussed in this review mainly over last eight years (2017-April 2024).

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来源期刊

Chemical record 化学-化学综合

CiteScore

11.00

自引率

3.00%

发文量

188

审稿时长

>12 weeks

期刊介绍： The Chemical Record (TCR) is a "highlights" journal publishing timely and critical overviews of new developments at the cutting edge of chemistry of interest to a wide audience of chemists (2013 journal impact factor: 5.577). The scope of published reviews includes all areas related to physical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, polymer chemistry, materials chemistry, bioorganic chemistry, biochemistry, biotechnology and medicinal chemistry as well as interdisciplinary fields. TCR provides carefully selected highlight papers by leading researchers that introduce the author''s own experimental and theoretical results in a framework designed to establish perspectives with earlier and contemporary work and provide a critical review of the present state of the subject. The articles are intended to present concise evaluations of current trends in chemistry research to help chemists gain useful insights into fields outside their specialization and provide experts with summaries of recent key developments.