绝经后原发性获得性鼻泪管梗阻合并梗阻性睑板腺功能障碍患者的泪细胞因子和乳铁蛋白水平变化

IF 1.7 4区 医学 Q3 OPHTHALMOLOGY
Haili Jin, Xianjie Chen, Feng Ji, Yin Liu, Yonghong Sheng, Guoping Wang, Linfeng Han, Xiaohu Wang, He Ding, Jing Liu, Qingqing Fu
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引用次数: 0

摘要

背景:眼显和继发性眼表损伤正日益影响人们的生活质量,尤其是老年妇女。本研究旨在探讨绝经后原发性获得性鼻泪管梗阻(PANDO)合并梗阻性睑板腺功能障碍(OMGD)患者泪细胞因子和乳铁蛋白水平的变化,并初步探讨PANDO患者OMGD的病理机制。方法:前瞻性研究分别纳入43例和41例有PANDO和无PANDO的绝经后妇女。根据是否存在OMGD,对参与者进行细分。使用Schirmer I试验从所有参与者的受影响眼睛收集泪液,并使用Multiplex Luminex Assay检测细胞因子浓度(白细胞介素(IL)-6、IL-8、IL-1β、干扰素- γ、肿瘤坏死因子(TNF)-α、IL-10、表皮生长因子(EGF))。ELISA法测定泪液乳铁蛋白水平。结果:PANDO + OMGD组IL-8、IL-1α、IL-1β、巨噬细胞炎性蛋白-1α水平显著高于其他各组。IL-6、TNF-α水平明显高于对照组。PANDO合并OMGD组乳铁蛋白水平低于Non-PANDO合并OMGD组。各组间IL-10和EGF水平无显著差异。结论:PANDO合并OMGD患者泪液中促炎因子水平明显升高,可能对眼表造成进一步损伤。抗炎治疗可能有助于保护绝经后PANDO妇女的眼表。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Changes in tear cytokine and lactoferrin levels in postmenopausal women with primary acquired nasolacrimal duct obstruction complicated with obstructed meibomian gland dysfunction.

Background: Epiphora and secondary ocular surface damage are increasingly impairing the quality of life of people, particularly elderly women. We aimed to investigate the changes in tear cytokine and lactoferrin levels in postmenopausal women with primary acquired nasolacrimal duct obstruction (PANDO) complicated with obstructed meibomian gland dysfunction (OMGD) and preliminary explore the pathological mechanisms of OMGD in patients with PANDO.

Methods: The prospective study involved 43 and 41 postmenopausal women with and without PANDO, respectively. Based on the presence or absence of OMGD, the participants were subdivided. Tear fluid was collected from affected eyes of all participants using Schirmer I test and tested for cytokine concentrations (interleukin (IL)-6, IL-8, IL-1β, interferon-gamma, tumour necrotic factor (TNF)-α, IL-10, epidermal growth factor (EGF)) using the Multiplex Luminex Assay. Tear lactoferrin levels was determined using ELISA.

Results: In the PANDO with OMGD group, the IL-8, IL-1α, IL-1β, and macrophage inflammatory protein-1α levels were significantly higher than those in the other groups. The IL-6 and TNF-α levels were significantly higher than those in the controls. The lactoferrin level in the PANDO with OMGD group was lower than that in the Non-PANDO with OMGD group. The IL-10 and EGF levels were not significantly different among the groups.

Conclusion: The level of pro-inflammatory factors in the tears of patients with PANDO complicated with OMGD was significantly increased, which is likely to cause further damage to ocular surface. Anti-inflammatory therapy may help protect ocular surface in postmenopausal women with PANDO.

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来源期刊
BMC Ophthalmology
BMC Ophthalmology OPHTHALMOLOGY-
CiteScore
3.40
自引率
5.00%
发文量
441
审稿时长
6-12 weeks
期刊介绍: BMC Ophthalmology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of eye disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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