解决术后腹部粘连的新策略：Janus水凝胶。

IF 5.4 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-01-14 DOI:10.1016/j.colsurfb.2025.114511

Xinhui Zhu , Lipeng Zhang , Yingcheng Qi , Jingyu Zhang , Fuxin Tang , Zhen Zong

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引用次数: 0

摘要

腹部粘连是腹部手术后常见的并发症，它会给患者带来巨大的疼痛和负担。尽管有多种治疗方法，包括手术干预和药物治疗，但这些方法往往不能持续有效地预防术后腹部粘连。Janus水凝胶以其不对称的特性而闻名，在预防和治疗腹部粘连方面有很大的前景。本文综述了Janus水凝胶的制备方法、作用机制以及在预防术后腹腔粘连中的主要应用。此外，我们研究了目前Janus水凝胶抗粘附屏障的局限性，并探讨了其潜在的未来发展方向。

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A novel strategy for addressing post-surgical abdominal adhesions: Janus hydrogel

Abdominal adhesions are a frequent complication after abdominal surgery, which can cause significant pain and burden to patients. Despite various treatment options, including surgical intervention and pharmacotherapy, these often fail to consistently and effectively prevent postoperative abdominal adhesions. Janus hydrogel is famous for its asymmetric characteristics, which shows great prospects in the prevention and treatment of abdominal adhesion. This review outlines the preparation methods, mechanisms of action, and key applications of Janus hydrogel in the prevention of postoperative abdominal adhesions. Furthermore, we examine the current limitations of the Janus hydrogel anti-adhesion barrier and explore potential future directions for its development.

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.