纳米圆盘中的膜蛋白：方法和应用。

IF 3.6 4区医学 Q2 CHEMISTRY, MEDICINAL

ChemMedChem Pub Date : 2025-01-18 DOI:10.1002/cmdc.202400775

Jiaxu Guo, Qinghan Hou, Yulin Tan, Ruoheng Fu, Xuanwei Huang, Chan Cao

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引用次数: 0

摘要

膜蛋白是一类重要的药物靶点，在各种生物过程中起着不可或缺的作用，与生命的基本功能密切相关。然而，由于它们在水环境中的低溶解度和独特的结构特征，它们的研究变得复杂，需要一个合适的类似天然的环境来进行分子分析。纳米盘技术已经彻底改变了这一领域，为生物化学家提供了一个强大的工具来稳定膜蛋白，并显著提高了他们的研究可能性。本文概述了2018年至2024年纳米圆盘方法和应用的实质性进展。我们涵盖了各种纳米圆盘模型的发展，以及利用纳米圆盘的膜蛋白的结构和功能研究，重点介绍了它们的医学应用。

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Membrane Proteins in Nanodiscs: Methods and Applications.

Membrane proteins, a principal class of drug targets, play indispensable roles in various biological processes and are closely associated with essential life functions. Their study, however, is complicated by their low solubility in aqueous environments and distinctive structural characteristics, necessitating a suitable native-like environment for molecular analysis. Nanodisc technology has revolutionized this field, providing biochemists with a powerful tool to stabilize membrane proteins and significantly enhance their research possibilities. This review outlines the substantial advancements in nanodisc methodologies and applications from 2018 to 2024. We cover the development of various nanodisc models, as well as structural and functional studies of membrane proteins that utilize nanodiscs, highlighting their medical applications.

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来源期刊

ChemMedChem 医学-药学

CiteScore

6.70

自引率

2.90%

发文量

280

审稿时长

1 months

期刊介绍： Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs. Contents ChemMedChem publishes an attractive mixture of: Full Papers and Communications Reviews and Minireviews Patent Reviews Highlights and Concepts Book and Multimedia Reviews.