用于药物输送和生物传感的微针的定制设计。

IF 4.5 2区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Molecular Pharmaceutics Pub Date : 2025-01-15 DOI:10.1021/acs.molpharmaceut.4c01266

Yuexi Lin, Muamer Dervisevic, Hao Zhe Yoh, Keying Guo, Nicolas H Voelcker

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引用次数: 0

摘要

微针（MNs）正在成为治疗药物输送和诊断监测的多功能工具。与皮下注射针头不同，MNs以最小或没有疼痛和可定制的设计实现这些应用，使其适合个性化医疗。了解生物流体接触过程中的关键设计参数和挑战对于优化其在各种应用中的使用至关重要。本文综述了当前的制造技术和设计考虑，以满足药物输送和生物传感应用的不同要求。我们进一步强调了结合药物传递和生物传感的治疗性MNs的现状，并提出了将MNs推向临床应用的未来方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Tailoring Design of Microneedles for Drug Delivery and Biosensing.

Microneedles (MNs) are emerging as versatile tools for both therapeutic drug delivery and diagnostic monitoring. Unlike hypodermic needles, MNs achieve these applications with minimal or no pain and customizable designs, making them suitable for personalized medicine. Understanding the key design parameters and the challenges during contact with biofluids is crucial to optimizing their use across applications. This review summarizes the current fabrication techniques and design considerations tailored to meet the distinct requirements for drug delivery and biosensing applications. We further underscore the current state of theranostic MNs that integrate drug delivery and biosensing and propose future directions for advancing MNs toward clinical use.

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来源期刊

Molecular Pharmaceutics 医学-药学

CiteScore

8.00

自引率

6.10%

发文量

391

审稿时长

2 months

期刊介绍： Molecular Pharmaceutics publishes the results of original research that contributes significantly to the molecular mechanistic understanding of drug delivery and drug delivery systems. The journal encourages contributions describing research at the interface of drug discovery and drug development. Scientific areas within the scope of the journal include physical and pharmaceutical chemistry, biochemistry and biophysics, molecular and cellular biology, and polymer and materials science as they relate to drug and drug delivery system efficacy. Mechanistic Drug Delivery and Drug Targeting research on modulating activity and efficacy of a drug or drug product is within the scope of Molecular Pharmaceutics. Theoretical and experimental peer-reviewed research articles, communications, reviews, and perspectives are welcomed.