解锁神经炎症：朊病毒疾病治疗的平衡艺术。

IF 4.1 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

ACS Chemical Neuroscience Pub Date : 2025-01-21 DOI:10.1021/acschemneuro.4c00871

Cao Chen, Xiaoping Dong

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引用次数: 0

摘要

神经炎症在朊病毒疾病中起着双重作用，既有助于清除错误折叠的痒病样朊病毒蛋白，又有助于通过炎症途径的慢性激活引起神经病理。关键机制，包括M-CSF/CSF1R信号，NLRP3炎症小体激活，半乳糖凝集素-3/TREM2轴等，突出了针对神经炎症进行治疗干预的复杂性。平衡这些通路的调节，同时保持有益的免疫反应和维持血脑屏障的完整性对于开发有效的治疗方法至关重要。

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Unlocking Neuroinflammation: A Balanced Art for Therapeutics of Prion Disease.

Neuroinflammation plays a dual role in prion diseases, contributing both to the clearance of misfolded scrapie-like prion protein and to neuropathology through chronic activation of inflammatory pathways. Key mechanisms, including M-CSF/CSF1R signaling, NLRP3 inflammasome activation, and the Galectin-3/TREM2 axis, etc., highlight the complexity of targeting neuroinflammation for therapeutic intervention. Balancing the modulation of these pathways while preserving beneficial immune responses and maintaining blood-brain barrier integrity is critical for developing effective treatments.

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来源期刊

ACS Chemical Neuroscience BIOCHEMISTRY & MOLECULAR BIOLOGY-CHEMISTRY, MEDICINAL

CiteScore

9.20

自引率

4.00%

发文量

323

审稿时长

1 months

期刊介绍： ACS Chemical Neuroscience publishes high-quality research articles and reviews that showcase chemical, quantitative biological, biophysical and bioengineering approaches to the understanding of the nervous system and to the development of new treatments for neurological disorders. Research in the journal focuses on aspects of chemical neurobiology and bio-neurochemistry such as the following: Neurotransmitters and receptors Neuropharmaceuticals and therapeutics Neural development—Plasticity, and degeneration Chemical, physical, and computational methods in neuroscience Neuronal diseases—basis, detection, and treatment Mechanism of aging, learning, memory and behavior Pain and sensory processing Neurotoxins Neuroscience-inspired bioengineering Development of methods in chemical neurobiology Neuroimaging agents and technologies Animal models for central nervous system diseases Behavioral research