镁二价离子在不同摩尔浓度下对迪克森DNA序列影响的简要研究

IF 2.8 3区物理与天体物理 Q2 PHYSICS, MULTIDISCIPLINARY

The European Physical Journal Plus Pub Date : 2025-01-22 DOI:10.1140/epjp/s13360-025-06000-0

Angad Sharma, Rakesh Kumar Mishra

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引用次数: 0

摘要

核酸与金属离子的相互作用对DNA的功能至关重要。Mg2+可以通过水直接或间接结合。研究了在固定NaCl浓度下Mg2+与Dickerson DNA在不同浓度下的相互作用。通过分析相关函数，我们绘制了DNA区域周围的Mg2+密度图。我们发现Mg2+的相互作用随着Mg2+浓度的升高而降低。Mg2+对凹槽上的磷酸基团也表现出更高的亲和力。我们通过Mg2+浓度的变化探索了堆叠参数的变化，表明了尚未探索的轻微结构变化。我们的研究表明，Mg2+浓度对Dickerson-DNA结构的影响几乎最小，反而稳定了它。

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A brief study of the effects of magnesium divalent ions on the Dickerson DNA sequence at varying molar concentrations

The interaction of nucleic acids with metallic ions is crucial for DNA function. Mg²⁺ can bond directly or indirectly via water. We explored Mg²⁺ interaction with Dickerson DNA at varying Mg²⁺ concentrations with fixed NaCl concentration. Analysing the correlation function, we mapped Mg²⁺ density around DNA regions. We found that the Mg²⁺ interaction decreased with rising Mg²⁺ concentrations. Mg²⁺ also displayed a higher affinity for the Phosphate group over grooves. We explored the variation of stacking parameters by varying Mg²⁺ concentrations, indicating slight structural changes which have not been explored yet. Our study reflects that the Mg²⁺ concentrations had almost minimal impact on Dickerson-DNA structure, instead stabilizing it.

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来源期刊

The European Physical Journal Plus PHYSICS, MULTIDISCIPLINARY-

CiteScore

5.40

自引率

8.80%

发文量

1150

审稿时长

4-8 weeks

期刊介绍： The aims of this peer-reviewed online journal are to distribute and archive all relevant material required to document, assess, validate and reconstruct in detail the body of knowledge in the physical and related sciences. The scope of EPJ Plus encompasses a broad landscape of fields and disciplines in the physical and related sciences - such as covered by the topical EPJ journals and with the explicit addition of geophysics, astrophysics, general relativity and cosmology, mathematical and quantum physics, classical and fluid mechanics, accelerator and medical physics, as well as physics techniques applied to any other topics, including energy, environment and cultural heritage.