头孢替坦与氨基糖苷对甲氧西林敏感和耐药的金黄色葡萄球菌和凝固酶阴性葡萄球菌的体外相互作用

Chemioterapia : international journal of the Mediterranean Society of Chemotherapy Pub Date : 1988-06-01

S Stefani, E Debbia, G C Schito, G Nicoletti

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引用次数: 0

摘要

作者评估了头孢替坦(一种对β -内酰胺酶具有长期耐药性的新型头孢菌素)与庆大霉素、阿米卡星和奈替米星对甲氧西林敏感和耐药葡萄球菌的相互作用。65.8%的病例显示联合用药有协同作用。结果细分为对联合用药的敏感性或耐药性。一般来说，当两种药物对甲氧西林敏感菌株进行试验时，结果显示出协同作用。

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In vitro interaction between cefotetan and aminoglycosides on Staphylococcus aureus and coagulase negative staphylococci, both methicillin-susceptible and -resistant.

The authors have evaluated the behavior of the interaction between cefotetan, a new cephalosporin with long acting resistance to the action of beta-lactamases, and gentamicin, amikacin and netilmicin against methicillin-susceptible and -resistant staphylococci. In 65.8% of the cases, drug combinations showed synergic effects. Results were subdivided for susceptibility or resistance to the drugs used in combination. In general, when both drugs were tested against methicillin-susceptible strains the results showed synergism.

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Chemioterapia : international journal of the Mediterranean Society of Chemotherapy

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