饱和氮杂环、胺和酰胺的区域和立体选择性β-C(sp3) - h活化/功能化

IF 4.4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2025-01-20 DOI:10.1002/adsc.202401398

Sanjay Yadav, Murugesh V, Surisetti Suresh

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引用次数: 0

摘要

饱和氮杂环、胺/酰胺的区域和立体选择性β-C(sp3) - h键功能化具有挑战性，已成为C(sp3) - h活化领域的一个重要研究课题。在此，我们总结了各种β-C(sp3) -H活化/功能化方法；本文综述了饱和氮杂环、胺类/酰胺类β-C(sp3) -H键活化/功能化的各种研究趋势。根据反应途径分为区域选择性和立体选择性β-C(sp3) - h键激活方法。文献方法包括指导基团或配体辅助反应，通过烯胺中间体进行的反应，氧化还原中性方法以及其他趋势方法，包括光氧化还原和过渡金属无方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Regio- and Stereoselective β-C(sp3)‒H Activation/ Functionalization of Saturated Nitrogen Heterocycles, Amines and Amides

Regio- and stereoselective β-C(sp3)‒H bond functionalizations of saturated nitrogen heterocycles, amines/amides are challenging and have emerged as an important topic of research in the area of C(sp3)‒H activation. Herein, we have summarized various β-C(sp3)‒H activation/functionalization methods; this review provides an overview of various trending approaches for β-C(sp3)‒H bond activation/functionalization of saturated nitrogen heterocycles, amines/amides. The regio- and stereoselective β-C(sp3)‒H bond activation methods are classified based on the reaction pathways. The literature methods including directing group or ligand-assisted reactions, reactions proceeding through enamine intermediate, redox-neutral methods and other trending methods including photoredox and transitional metal-free methods are discussed with recent updates.

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.