甘露糖：T细胞免疫疗法的游戏规则改变者

IF 27.7 1区生物学 Q1 CELL BIOLOGY

Cell metabolism Pub Date : 2025-01-17 DOI:10.1016/j.cmet.2024.12.014

Jingwei Ma, Shuai Tong, Jingxuan Xiao, Bo Huang

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引用次数: 0

摘要

代谢影响各种免疫细胞类型的行为。在最近的一项Cancer Cell研究中，Qiu等人发现甘露糖代谢是肿瘤前体耗竭T细胞（Tpex）的一个重要代谢特征，对维持T细胞的干细胞性至关重要。他们的工作揭示了一种新的代谢机制，使T细胞增殖与分化脱钩，为代谢调节如何在制造过程中用于产生“更好”的T细胞提供了有价值的见解。

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Mannose: A game-changer for T cell immunotherapy

Metabolism influences the behavior of various immune cell types. In a recent Cancer Cell study, Qiu et al. revealed mannose metabolism as a prominent metabolic feature of tumor precursor exhausted T cells (Tpex) that is crucial for maintaining T cell stemness. Their work uncovers a novel metabolic mechanism that decouples T cell proliferation from differentiation, providing valuable insights into how metabolic modulation can be used to generate “better” T cells during the manufacturing process.

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来源期刊

Cell metabolism 生物-内分泌学与代谢

CiteScore

48.60

自引率

1.40%

发文量

173

审稿时长

2.5 months

期刊介绍： Cell Metabolism is a top research journal established in 2005 that focuses on publishing original and impactful papers in the field of metabolic research.It covers a wide range of topics including diabetes, obesity, cardiovascular biology, aging and stress responses, circadian biology, and many others. Cell Metabolism aims to contribute to the advancement of metabolic research by providing a platform for the publication and dissemination of high-quality research and thought-provoking articles.