人类和非人类灵长类动物牙周病口腔微生物群综述：当前问题和观点。

IF 2.2 4区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Archives of oral biology Pub Date : 2024-11-10 DOI:10.1016/j.archoralbio.2024.106121

Bruno Pires Miranda , Amanda Figueira da Silva , Júlia de Castro Ascenção , Helena Lúcia Carneiro Santos

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引用次数: 0

摘要

目的：全面总结人类和非人类灵长类动物口腔微生物群与牙周病病因的关系。设计：通过检索MEDLINE/PubMed、虚拟健康图书馆和SciELO数据库，对2010年至2024年间发表的398篇临床和观察性文章进行综合文献综述。经过筛选、入选、数据提取和方法学质量评估，共选择21项研究。结果：这些结果揭示了人类牙周病病原体与NHPs之间惊人的相似性，证实了NHPs作为研究模型的潜力，并启发了该领域的进一步研究。结论：根据这些研究，放线菌、放线菌聚合菌、直弯曲菌、嗜糖菌、真杆菌、嗜酸丝状杆菌、梭杆菌、细毛纤毛菌、粘膜奈瑟菌、微细小单胞菌、卟啉单胞菌、普雷沃菌、硒单胞菌、链球菌、密螺旋体、坦纳菌、小叶细孔菌是在人体中发现的细菌属或种。另方面，NHPs中报告最多的是放线菌聚集菌、直弯曲菌、Desulfobulbus、Dialister invisus、Eikenella crodens、Filifactor alocis、Fusobacterium、Parvimonas micra、Porphyromonas spp、Prevotella spp、Staphylococcus spp、Streptococcus spp、Treponema spp、Tannerella spp、Veillonella spp。在非人类灵长类动物中没有研究报告原生动物的存在，而在人类研究中报告了牙龈内阿米巴和毛滴虫的存在。然而，它在牙周病中的作用仍然需要阐明，尽管它主要与严重的牙周病密切相关，在受伤的组织中观察到原生动物。

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An overview of the microbiota of the oral cavity of humans and non-human primates with periodontal disease: Current issues and perspectives

Objective

To provide a comprehensive summary of the available evidence on the oral microbiota of humans and non-human primates about the etiology of periodontal disease.

Design

An integrative literature review was conducted on 398 clinical and observational articles published between 2010 and 2024 using searches in the MEDLINE/PubMed, Virtual Health Library, and SciELO databases. After the screening, eligibility, data extraction, and methodological quality assessment, 21 studies were selected.

Results

The results, which reveal striking similarities between the pathogens involved in periodontal disease in humans and NHPs, confirm the potential of NHPs as research models and inspire further research in this area.

Conclusion

According to these studies, Actinomyces spp., Aggregatibacter actinomycetemcomitans, Campylobacter rectus, Capnocytophaga spp., Eubacterium spp., Filifactor alocis, Fusobacterium spp., Leptotrichia spp., Neisseria mucosa, Parvimonas micra, Porphyromonas spp., Prevotella spp., Selenomonas spp., Streptococcus spp., Treponema spp., Tannerella spp., Veillonella parvula, were the genus and/or species of bacteria found in humans. On the other hand, Aggregatibacter acinomycetemcomitans, Campylobacter rectus, Desulfobulbus spp., Dialister invisus, Eikenella corrodens, Filifactor alocis, Fusobacterium spp., Parvimonas micra, Porphyromonas spp., Prevotella spp., Staphylococcus spp., Streptococcus spp., Treponema spp., Tannerella spp., Veillonella spp., were the most reported in NHPs. No study in non-human primates reported the presence of protozoa, unlike studies in humans that reported the presence of Entamoeba gingivalis and Trichomonas tenax. However, its role in periodontal disease still needs to be elucidated, despite the strong association mainly with severe periodontal disease where protozoa are observed in injured tissues.

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来源期刊

Archives of oral biology 医学-牙科与口腔外科

CiteScore

5.10

自引率

3.30%

发文量

177

审稿时长

26 days

期刊介绍： Archives of Oral Biology is an international journal which aims to publish papers of the highest scientific quality in the oral and craniofacial sciences. The journal is particularly interested in research which advances knowledge in the mechanisms of craniofacial development and disease, including: Cell and molecular biology Molecular genetics Immunology Pathogenesis Cellular microbiology Embryology Syndromology Forensic dentistry