在胰腺癌小鼠模型中，局部炎症先于膈肌萎缩和纤维化重构

IF 8.9 1区医学

Journal of Cachexia, Sarcopenia and Muscle Pub Date : 2025-01-15 DOI:10.1002/jcsm.13668

Daria Neyroud, Andrew C. D'Lugos, Enrique J. Trevino, Chandler S. Callaway, Jacqueline Lamm, Orlando Laitano, Brittney Poole, Michael R. Deyhle, Justina Brantley, Lam Le, Andrew R. Judge, Sarah M. Judge

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引用次数: 0

摘要

癌症恶病质代表了一种衰弱的肌肉萎缩状态，在胃肠道癌症中非常普遍，包括胰腺导管腺癌（PDAC）。据估计，恶病质导致约30%的癌症相关死亡，而呼吸肌的恶化被怀疑是恶病质相关发病率和死亡率的关键因素。在最近的研究中，我们发现呼吸副肌的纤维化重构是人类PDAC恶病质的一个关键特征。

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Local Inflammation Precedes Diaphragm Wasting and Fibrotic Remodelling in a Mouse Model of Pancreatic Cancer

Cancer cachexia represents a debilitating muscle wasting condition that is highly prevalent in gastrointestinal cancers, including pancreatic ductal adenocarcinoma (PDAC). Cachexia is estimated to contribute to ~30% of cancer-related deaths, with deterioration of respiratory muscles suspected to be a key contributor to cachexia-associated morbidity and mortality. In recent studies, we identified fibrotic remodelling of respiratory accessory muscles as a key feature of human PDAC cachexia.

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来源期刊

Journal of Cachexia, Sarcopenia and Muscle Medicine-Orthopedics and Sports Medicine

自引率

12.40%

发文量

期刊介绍： The Journal of Cachexia, Sarcopenia, and Muscle is a prestigious, peer-reviewed international publication committed to disseminating research and clinical insights pertaining to cachexia, sarcopenia, body composition, and the physiological and pathophysiological alterations occurring throughout the lifespan and in various illnesses across the spectrum of life sciences. This journal serves as a valuable resource for physicians, biochemists, biologists, dieticians, pharmacologists, and students alike.