血管老化表现与社区高血压。

IF 4.3 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

American journal of preventive cardiology Pub Date : 2024-12-13 DOI:10.1016/j.ajpc.2024.100918

Guillermo A. Alanis , Pierre Boutouyrie , Mouad Abouqateb , Rosa Maria Bruno , Rachel E. Climie , Thomas van Sloten , Nicolas Danchin , Bruno Pannier , Stéphane Laurent , Xavier Jouven , Jean-Philippe Empana

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引用次数: 0

摘要

目的：探讨血管老化（VA）关节表现与高血压的关系。方法：我们使用了巴黎前瞻性研究III的基线（2008-2012年）和随访数据（至2024年），该研究是一项包含10,157名参与者的法国队列研究。在基线（血压≥140/90 mmHg或服药时）和随访2、4、6、8和10年（自我报告抗高血压治疗情况）时确定高血压的患病率和发生率。通过右颈总动脉回声追踪在基线时评估VA表现。聚类分析确定了VA的模式，并通过逻辑回归评估了它们与高血压的关系。结果：横断面分析包括9096名参与者（平均年龄：59±6岁，39%为女性）。高血压患病率为36% （n = 3276）。确定了三组VA表现。第1组（n = 4,326, 47.6%）的特征是血管健康老化（HVA），第2组动脉硬化（ART）增加（n = 2,274, 25.0%），第3组动脉粥样硬化患病率较高（ATH）（n = 2,496, 27.4%）。与HVA集群相比，ART (aOR 3.94；95% CI 3.50;4.45)和ATH集群(aOR 2.69；95% CI 2.38;3.04)与高血压相关。前瞻性分析包括5310例血压正常者和754例（14.1%）高血压病例（中位随访10.05年[范围：10.00;10.15]）。ART (aOR 1.34；95% CI 1.08;1.65)和ATH (aOR 1.70；95% CI 1.40;2.07)与高血压事件相关。结论：颈动脉硬化和动脉粥样硬化的血管老化表现与高血压的流行和发生有关。

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Vascular ageing manifestations and hypertension in the community

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Vascular ageing manifestations and hypertension in the community

Objective

To investigate the association between joint manifestations of vascular ageing (VA) and hypertension.

Methods

We used baseline (2008–2012) and follow-up data (up to 2024) from the Paris Prospective Study III, a French cohort of 10,157 participants. Prevalent and incident hypertension were determined at baseline (blood pressure ≥140/90 mmHg or on medication) and at 2, 4, 6, 8 and 10 years of follow-up (self-reported antihypertensive treatment). VA manifestations were assessed at baseline via echo-tracking in the right common carotid artery. Clustering analysis identified patterns of VA and their association with hypertension was assessed with logistic regression.

Results

The cross-sectional analysis included 9,096 participants (mean age: 59±6 years, 39 % female). Hypertension prevalence was 36 % (n = 3,276). Three clusters of VA manifestations were identified. Cluster 1 (n = 4,326;47.6 %) was characterized by healthy vascular ageing (HVA), Cluster 2 by increased arteriosclerosis (ART) (n = 2,274;25.0 %) and Cluster 3 by greater atherosclerosis prevalence (ATH) (n = 2,496;27.4 %). Compared to the HVA cluster, ART (aOR 3.94; 95 % CI 3.50;4.45) and ATH clusters (aOR 2.69; 95 % CI 2.38;3.04) were associated with prevalent hypertension. The prospective analysis included 5,310 normotensives with 754 (14.1 %) cases of incident hypertension (median follow-up of 10.05 years [range: 10.00;10.15]). Both ART (aOR 1.34; 95 % CI 1.08;1.65) and ATH (aOR 1.70; 95 % CI 1.40;2.07) clusters were associated with incident hypertension.