{"title":"慢性淋巴细胞白血病/小淋巴细胞淋巴瘤向血管免疫母细胞t细胞淋巴瘤转化一例罕见病例。","authors":"Hongjuan Yu, Xuefen Qi, Jifei Zhang, Lingrong He","doi":"10.7754/Clin.Lab.2024.240743","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Angioimmunoblastic T-cell lymphoma (AITL) is a distinct subtype of peripheral T-cell lymphoma (PTCL) and accounts for 2% of all non-Hodgkin lymphomas. Its typical characteristics include an aggressive course, progressive lymphadenopathy, hepatosplenomegaly, systemic symptoms, anemia, hypergammaglobulinemia, and generally poor prognosis.</p><p><strong>Methods: </strong>We describe a rare case in which the left inguinal lymph node was completely excised and biopsied one year ago. Based on histomorphology and immunohistochemistry, B-cell small lymphocytic lymphoma (CLL/SLL) was diagnosed. Routine bone marrow examination indicated the presence of immature lymphocytes; however, immunophenotyping showed no significant abnormal lymphocytes. One month ago, the patient developed swelling in the left lower limb, which gradually worsened. A fine-needle aspiration biopsy of the left inguinal lymph node revealed angioimmunoblastic T-cell lymphoma.</p><p><strong>Results: </strong>The final diagnosis for this patient is a transformation from B-cell small lymphocytic lymphoma to angioimmunoblastic T-cell lymphoma (AITL) one year after the initial diagnosis.</p><p><strong>Conclusions: </strong>In this report, we present a rare case of AITL. The aim is to enhance awareness among readers regarding the clinical, immunological, and phenotypic characteristics of various forms of AITL.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 1","pages":""},"PeriodicalIF":0.7000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Conversion of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma to Angioimmunoblastic T-cell Lymphoma: a Rare Case.\",\"authors\":\"Hongjuan Yu, Xuefen Qi, Jifei Zhang, Lingrong He\",\"doi\":\"10.7754/Clin.Lab.2024.240743\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Angioimmunoblastic T-cell lymphoma (AITL) is a distinct subtype of peripheral T-cell lymphoma (PTCL) and accounts for 2% of all non-Hodgkin lymphomas. Its typical characteristics include an aggressive course, progressive lymphadenopathy, hepatosplenomegaly, systemic symptoms, anemia, hypergammaglobulinemia, and generally poor prognosis.</p><p><strong>Methods: </strong>We describe a rare case in which the left inguinal lymph node was completely excised and biopsied one year ago. Based on histomorphology and immunohistochemistry, B-cell small lymphocytic lymphoma (CLL/SLL) was diagnosed. Routine bone marrow examination indicated the presence of immature lymphocytes; however, immunophenotyping showed no significant abnormal lymphocytes. One month ago, the patient developed swelling in the left lower limb, which gradually worsened. A fine-needle aspiration biopsy of the left inguinal lymph node revealed angioimmunoblastic T-cell lymphoma.</p><p><strong>Results: </strong>The final diagnosis for this patient is a transformation from B-cell small lymphocytic lymphoma to angioimmunoblastic T-cell lymphoma (AITL) one year after the initial diagnosis.</p><p><strong>Conclusions: </strong>In this report, we present a rare case of AITL. The aim is to enhance awareness among readers regarding the clinical, immunological, and phenotypic characteristics of various forms of AITL.</p>\",\"PeriodicalId\":10384,\"journal\":{\"name\":\"Clinical laboratory\",\"volume\":\"71 1\",\"pages\":\"\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical laboratory\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.7754/Clin.Lab.2024.240743\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICAL LABORATORY TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical laboratory","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.7754/Clin.Lab.2024.240743","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}
Conversion of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma to Angioimmunoblastic T-cell Lymphoma: a Rare Case.
Background: Angioimmunoblastic T-cell lymphoma (AITL) is a distinct subtype of peripheral T-cell lymphoma (PTCL) and accounts for 2% of all non-Hodgkin lymphomas. Its typical characteristics include an aggressive course, progressive lymphadenopathy, hepatosplenomegaly, systemic symptoms, anemia, hypergammaglobulinemia, and generally poor prognosis.
Methods: We describe a rare case in which the left inguinal lymph node was completely excised and biopsied one year ago. Based on histomorphology and immunohistochemistry, B-cell small lymphocytic lymphoma (CLL/SLL) was diagnosed. Routine bone marrow examination indicated the presence of immature lymphocytes; however, immunophenotyping showed no significant abnormal lymphocytes. One month ago, the patient developed swelling in the left lower limb, which gradually worsened. A fine-needle aspiration biopsy of the left inguinal lymph node revealed angioimmunoblastic T-cell lymphoma.
Results: The final diagnosis for this patient is a transformation from B-cell small lymphocytic lymphoma to angioimmunoblastic T-cell lymphoma (AITL) one year after the initial diagnosis.
Conclusions: In this report, we present a rare case of AITL. The aim is to enhance awareness among readers regarding the clinical, immunological, and phenotypic characteristics of various forms of AITL.
期刊介绍：
Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.
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