Xymedon与l-抗坏血酸在水溶液中的相互作用

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2025-01-14 DOI:10.1007/s11172-024-4455-8

V. Yu. Ivanova, V. V. Chevela, M. S. Shashin, V. E. Semenov, R. R. Zainulin

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引用次数: 0

摘要

采用电位滴定法、紫外可见光谱法和平衡数学模拟（CPESSP程序）研究了Xymedon（1,2-二氢-1-（2-羟乙基）-2-氧-4,6-二甲基嘧啶，1）与l-抗坏血酸(2)在水溶液中的相互作用。1…2缔合物的形成是在C2: C1摩尔比发生很大变化的情况下发生的，并测定了其酸度常数：pKa，111 = 4.95。

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Interaction of Xymedon with l-ascorbic acid in an aqueous solution

The interaction of Xymedon (1,2-dihydro-1-(2-hydroxyethyl)-2-oxo-4,6-dimethyl-pyrimidine, 1) and l-ascorbic acid (2) in an aqueous solution was studied by the methods of potentiometric titration, spectroscopy in the UV—visible range, and mathematical simulation of equilibria (CPESSP program). The formation of a 1…2 associate was shown to take place at a wide change in the C₂: C₁ molar ratio, and its acidity constant was determined: pK_a,111 = 4.95.

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.