2-氨基-1-（3-氰基-4,5,6,7-四氢苯并[b]噻吩-2-基）-4-氧-4,5-二氢- 1h -吡咯-3-羧酸衍生物的合成及其对黑色素瘤细胞系B16-F10的抗肿瘤活性研究

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2025-01-14 DOI:10.1007/s11172-024-4453-x

I. A. Gorbunova, A. Rogova, K. Yu. Parkhoma, D. A. Shipilovskikh, T. E. Karpov, R. R. Makhmudov, A. S. Timin, S. A. Shipilovskikh

引用次数: 0

摘要

拓宽了噻吩环上3位含腈基的2-氨基-4-氧-1-（3-氰基-4,5,6,7-四氢苯并[b]-噻吩-2-基）-4,5-二氢- 1h -吡咯-3羧酸衍生物的范围。研究了B16-F10对小鼠黑色素瘤细胞系的抗肿瘤活性。

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Synthesis of 2-amino-1-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-4-oxo-4,5-dihydro-1H-pyrrole-3-carboxylic acid derivatives and studies of their antitumor activity against melanoma cell line B16-F10

A range of new derivatives of 2-amino-4-oxo-1-(3-cyano-4,5,6,7-tetrahydrobenzo[b]-thiophen-2-yl)-4,5-dihydro-1H-pyrrole-3-carboxylic acids bearing the nitrile group at the position 3 of the thiophene ring was broadened. Antitumor activity against the B16-F10 murine melanoma cell line was studied.

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.