Fengqin Wang, Jian An, Shiyue Zhang, Jingjing Ma, Xufeng Liang, Jianxia Zhang, Jia Pu, Yujia Meng, Yiqiao Bai, Wenqiang Yu, Yunhan Gao, Yingfang Jiang, Tingting Chen, Yong Yao and Yang Wang
{"title":"羰基锰包封的fe - mof作为h2o2响应的CO气体纳米发生器用于协同气体/化学动力学治疗","authors":"Fengqin Wang, Jian An, Shiyue Zhang, Jingjing Ma, Xufeng Liang, Jianxia Zhang, Jia Pu, Yujia Meng, Yiqiao Bai, Wenqiang Yu, Yunhan Gao, Yingfang Jiang, Tingting Chen, Yong Yao and Yang Wang","doi":"10.1039/D4NJ05085A","DOIUrl":null,"url":null,"abstract":"<p >The combination of chemodynamic therapy (CDT) and gas therapy holds significant promise for tumor treatment. In this study, we successfully synthesized an intelligent H<small><sub>2</sub></small>O<small><sub>2</sub></small>-responsive Fe-MOF nanotherapeutic agent, integrated with glucose oxidase (GOx) and manganese carbonyl (MnCO), to achieve synergistic cancer gas/CDT. Upon endocytosis by tumor cells, the nanotherapeutic agent catalyzes the conversion of endogenous glucose into gluconic acid and H<small><sub>2</sub></small>O<small><sub>2</sub></small>, which facilitates the release of CO gas and disrupts the energy supply. Subsequently, a Fenton reaction occurs between Fe-MOFs and intracellular H<small><sub>2</sub></small>O<small><sub>2</sub></small>, generating highly toxic hydroxyl radicals (˙OH) for CDT. Therefore, the engineered nanotherapeutic agent demonstrates a synergistic efficacy through CO gas therapy, reactive oxygen species (ROS)-mediated CDT, and energy starvation, effectively suppressing tumor growth.</p>","PeriodicalId":95,"journal":{"name":"New Journal of Chemistry","volume":" 3","pages":" 669-673"},"PeriodicalIF":2.5000,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Manganese carbonyl-encapsulated Fe-MOFs as a H2O2-responsive CO gas nanogenerator for synergistic gas/chemodynamic therapy†\",\"authors\":\"Fengqin Wang, Jian An, Shiyue Zhang, Jingjing Ma, Xufeng Liang, Jianxia Zhang, Jia Pu, Yujia Meng, Yiqiao Bai, Wenqiang Yu, Yunhan Gao, Yingfang Jiang, Tingting Chen, Yong Yao and Yang Wang\",\"doi\":\"10.1039/D4NJ05085A\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >The combination of chemodynamic therapy (CDT) and gas therapy holds significant promise for tumor treatment. In this study, we successfully synthesized an intelligent H<small><sub>2</sub></small>O<small><sub>2</sub></small>-responsive Fe-MOF nanotherapeutic agent, integrated with glucose oxidase (GOx) and manganese carbonyl (MnCO), to achieve synergistic cancer gas/CDT. Upon endocytosis by tumor cells, the nanotherapeutic agent catalyzes the conversion of endogenous glucose into gluconic acid and H<small><sub>2</sub></small>O<small><sub>2</sub></small>, which facilitates the release of CO gas and disrupts the energy supply. Subsequently, a Fenton reaction occurs between Fe-MOFs and intracellular H<small><sub>2</sub></small>O<small><sub>2</sub></small>, generating highly toxic hydroxyl radicals (˙OH) for CDT. Therefore, the engineered nanotherapeutic agent demonstrates a synergistic efficacy through CO gas therapy, reactive oxygen species (ROS)-mediated CDT, and energy starvation, effectively suppressing tumor growth.</p>\",\"PeriodicalId\":95,\"journal\":{\"name\":\"New Journal of Chemistry\",\"volume\":\" 3\",\"pages\":\" 669-673\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-12-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"New Journal of Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.rsc.org/en/content/articlelanding/2025/nj/d4nj05085a\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"New Journal of Chemistry","FirstCategoryId":"92","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2025/nj/d4nj05085a","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Manganese carbonyl-encapsulated Fe-MOFs as a H2O2-responsive CO gas nanogenerator for synergistic gas/chemodynamic therapy†
The combination of chemodynamic therapy (CDT) and gas therapy holds significant promise for tumor treatment. In this study, we successfully synthesized an intelligent H2O2-responsive Fe-MOF nanotherapeutic agent, integrated with glucose oxidase (GOx) and manganese carbonyl (MnCO), to achieve synergistic cancer gas/CDT. Upon endocytosis by tumor cells, the nanotherapeutic agent catalyzes the conversion of endogenous glucose into gluconic acid and H2O2, which facilitates the release of CO gas and disrupts the energy supply. Subsequently, a Fenton reaction occurs between Fe-MOFs and intracellular H2O2, generating highly toxic hydroxyl radicals (˙OH) for CDT. Therefore, the engineered nanotherapeutic agent demonstrates a synergistic efficacy through CO gas therapy, reactive oxygen species (ROS)-mediated CDT, and energy starvation, effectively suppressing tumor growth.
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