通过4 -氨基香豆素和丙炔醇之间的[3+3]环反应获得1,2 -二氢吡啶/吡啶融合香豆素

IF 2.5 3区化学 Q2 CHEMISTRY, ORGANIC

European Journal of Organic Chemistry Pub Date : 2025-02-24 DOI:10.1002/ejoc.202401244

Minghui Liu , Pengcheng Guan , Yujie Qu , Feng Yan , Feng Feng , Chengyu Wang

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引用次数: 0

摘要

我们开发了两种简便而多样化的化学选择性合成 1,2-二氢吡啶融合香豆素和吡啶香豆素的方法。由于底物易得、反应条件温和、官能团耐受性好，这些步骤对构建各种二氢吡啶融合香豆素和吡啶香豆素具有吸引力，可丰富和发展杂环化学和药物化学。

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Access to 1, 2‐Dihydropyridine/Pyridine‐Fused Coumarins through [3+3] Annulation between 4‐Aminocoumarins and Propargylic Alcohols

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Access to 1, 2‐Dihydropyridine/Pyridine‐Fused Coumarins through [3+3] Annulation between 4‐Aminocoumarins and Propargylic Alcohols

Two facile and diversified protocols for the chem‐selective synthesis of 1,2‐dihydropyridine‐fused coumarins and pyridocoumarins have been developed. Readily accessible substrates, mild reaction conditions and good functional group tolerance make these procedures attractive for the construction of various dihydropyridine‐fused coumarins and pyridocoumarins, which may enrich and develop the heterocyclic chemistry and medicinal chemistry.

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.