骨髓细胞在癌症中遇到CD8+ T细胞衰竭:什么,为什么和如何。

IF 7 2区 医学 Q1 ONCOLOGY
Yijie Zhai, Xiaoting Liang, Mi Deng
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引用次数: 0

摘要

衰竭T细胞(Tex)是T细胞功能障碍的一种特殊状态,在慢性抗原刺激下,这些T细胞逐渐丧失其效应功能并改变其表型。肿瘤微环境中耗竭的CD8+ T细胞(CD8+ Tex)富集是导致免疫治疗效果不佳的重要原因之一。最近的研究报道了导致CD8+ T细胞衰竭的多种原因。除了癌细胞,骨髓细胞也可以通过多种方式促进T细胞衰竭。在这篇综述中,我们讨论了耗竭概念的历史,CD8+ T细胞功能障碍状态,CD8+ Tex的异质性,起源和特征。然后,我们重点研究骨髓细胞对CD8+ Tex的影响,包括肿瘤相关巨噬细胞(tam)、树突状细胞(DCs)和中性粒细胞。最后,我们系统地总结了目前治疗逆转和CD8+ T细胞衰竭的策略和最新进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Myeloid cells meet CD8+ T cell exhaustion in cancer: What, why and how.

Exhausted T cell (Tex) is a specific state of T cell dysfunction, in which these T cells gradually lose their effector function and change their phenotype during chronic antigen stimulation. The enrichment of exhausted CD8+ T cell (CD8+ Tex) in the tumor microenvironment is one of the important reasons leading to the poor efficacy of immunotherapy. Recent studies have reported many reasons leading to the CD8+ T cell exhaustion. In addition to cancer cells, myeloid cells can also contribute to T cell exhaustion via many ways. In this review, we discuss the history of the concept of exhaustion, CD8+ T cell dysfunction states, the heterogeneity, origin, and characteristics of CD8+ Tex. We then focus on the effects of myeloid cells on CD8+ Tex, including tumor-associated macrophages (TAMs), dendritic cells (DCs) and neutrophils. Finally, we systematically summarize current strategies and recent advancements in therapies reversing and CD8+ T cell exhaustion.

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来源期刊
自引率
9.80%
发文量
1726
审稿时长
4.5 months
期刊介绍: Chinese Journal of Cancer Research (CJCR; Print ISSN: 1000-9604; Online ISSN:1993-0631) is published by AME Publishing Company in association with Chinese Anti-Cancer Association.It was launched in March 1995 as a quarterly publication and is now published bi-monthly since February 2013. CJCR is published bi-monthly in English, and is an international journal devoted to the life sciences and medical sciences. It publishes peer-reviewed original articles of basic investigations and clinical observations, reviews and brief communications providing a forum for the recent experimental and clinical advances in cancer research. This journal is indexed in Science Citation Index Expanded (SCIE), PubMed/PubMed Central (PMC), Scopus, SciSearch, Chemistry Abstracts (CA), the Excerpta Medica/EMBASE, Chinainfo, CNKI, CSCI, etc.
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