非典型小细胞肺癌：一种以嗜色纤维化、类癌肿瘤和野生型RB1和TP53为特征的新恶性肿瘤。

IF 29.7 1区医学 Q1 ONCOLOGY

Cancer discovery Pub Date : 2025-01-13 DOI:10.1158/2159-8290.CD-24-1494

Urooba Nadeem, Benjamin J Drapkin

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引用次数: 0

摘要

小细胞肺癌（SCLC）和肺类癌传统上被认为是不相关的，SCLC与吸烟有关，并以RB1和TP53双等位基因缺失和快速进展为特征。Rekhtman和他的同事们通过发现一种“非典型”SCLC来颠覆这些假设，这种SCLC出现在具有完整RB1和TP53基因座的非吸烟者中，染色体缺陷诱导的染色体外DNA癌基因扩增，并且经常发生同步类癌肿瘤。参见Rekhtman等人的相关文章，第83页。

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Atypical Small Cell Lung Cancer: A New Malignancy Characterized by Chromothripsis, Carcinoid Tumors, and Wild-type RB1 and TP53.

Small cell lung cancer (SCLC) and pulmonary carcinoid tumors are traditionally seen as unrelated, with SCLC linked to smoking and characterized by biallelic loss of RB1 and TP53 and rapid progression. Rekhtman and colleagues upend these assumptions by discovering an "atypical" SCLC that arises in nonsmokers with intact RB1 and TP53 loci, chromothripsis-induced oncogene amplifications on extrachromosomal DNA, and frequent synchronous carcinoid tumors. See related article by Rekhtman et al., p. 83.

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来源期刊

Cancer discovery ONCOLOGY-

CiteScore

22.90

自引率

1.40%

发文量

838

审稿时长

6-12 weeks

期刊介绍： Cancer Discovery publishes high-impact, peer-reviewed articles detailing significant advances in both research and clinical trials. Serving as a premier cancer information resource, the journal also features Review Articles, Perspectives, Commentaries, News stories, and Research Watch summaries to keep readers abreast of the latest findings in the field. Covering a wide range of topics, from laboratory research to clinical trials and epidemiologic studies, Cancer Discovery spans the entire spectrum of cancer research and medicine.