对组成性中性粒细胞死亡的新认识。

IF 6.1 2区生物学 Q1 CELL BIOLOGY

Cell Death Discovery Pub Date : 2025-01-12 DOI:10.1038/s41420-025-02287-1

Tong Chen, Qian Ren, Fengxia Ma

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引用次数: 0

摘要

中性粒细胞经历快速衰老和死亡，称为构成性死亡或自发死亡。组成性中性粒细胞死亡（CND）有助于中性粒细胞稳态和炎症消退。CND一直被认为是凋亡，直到我们的发现揭示了它是多种死亡的异质组合。此外，死亡的中性粒细胞通过多种方式保留功能角色。本文就CND的机制和调控的研究现状作一综述。更值得注意的是，我们还总结了中性粒细胞死后的事件。中性粒细胞的命运可以在病理条件下改变，因此CND在疾病中的参与和CND相关的治疗策略也得到了解决。

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New insights into constitutive neutrophil death.

Neutrophils undergo rapid aging and death known as constitutive or spontaneous death. Constitutive neutrophil death (CND) contributes to neutrophil homeostasis and inflammation resolution. CND has long been considered to be apoptotic until our findings reveal that it was a heterogeneous combination of diverse death. Furthermore, dead neutrophils retain functional roles via multiple manners. This review provides an overview of current research on the mechanism and modulation of CND. More noteworthy, we also summarize the after-death events of neutrophils. The fate of neutrophils can be changed under pathological conditions, so the involvement of CND in diseases and CND-related therapeutic strategies are also addressed.

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来源期刊

Cell Death Discovery Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

8.30

自引率

1.40%

发文量

468

审稿时长

9 weeks

期刊介绍： Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research findings in Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death Discovery will build upon the success of Cell Death & Differentiation and Cell Death & Disease in publishing important peer-reviewed original research, timely reviews and editorial commentary. Cell Death Discovery is committed to increasing the reproducibility of research. To this end, in conjunction with its sister journals Cell Death & Differentiation and Cell Death & Disease, Cell Death Discovery provides a unique forum for scientists as well as clinicians and members of the pharmaceutical and biotechnical industry. It is committed to the rapid publication of high quality original papers that relate to these subjects, together with topical, usually solicited, reviews, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.