g -四联配合物修饰硫黄素T荧光发光Pb2+传感器的研制

IF 3.6 3区化学 Q2 CHEMISTRY, ANALYTICAL

Analyst Pub Date : 2025-01-13 DOI:10.1039/d4an01340a

Duyeop Kim, Do Yeon Kim, Ji Hoon Han

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引用次数: 0

摘要

我们开发了一种新型的、具有成本效益的荧光发光生物传感器，用于Pb 2 +检测，使用无标记的g -四联体结合修饰的硫黄素T （ThT）衍生物，利用独特的K + -Pb 2 + - g -四联体构象。其中T2 g -四联体与ThT-E的荧光增强效果最好，验证了其在实际水样中的高灵敏度和选择性

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Development of Novel Fluorescent Light-up Pb2+ Sensor Using G-quadruplex Complex with Modified Thioflavin T

We developed a novel, cost-effective fluorescent light-up biosensor for Pb²⁺ detection using a label-free G-quadruplex combined with modified Thioflavin T (ThT) derivatives, utilizing the unique K⁺-Pb²⁺-G-quadruplex conformation. Among them, the T2 G-quadruplex with ThT-E showed the best fluorescence enhancement, validating its high sensitivity and selectivity in real water samples

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