紫外线照射诱发的I型干扰素依赖激活和炎症树突细胞迁移到局部淋巴结

IF 11.4 1区医学 Q1 RHEUMATOLOGY

Arthritis & Rheumatology Pub Date : 2025-01-12 DOI:10.1002/art.43108

Xizhang Sun, Jaime L Chao, Michael Gerner, Keith B Elkon

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引用次数: 0

摘要

75%的狼疮患者有光敏性。虽然紫外线辐射（UVR）刺激皮肤中的I型干扰素（IFN-I），但UVR诱导的皮肤炎症如何导致下游效应尚不清楚。组织炎症导致DC从器官转移到引流淋巴结（dLN），包括最近发现的炎性DC亚群（inf cDC2），它们是有效的抗原提呈细胞。为了探索UVR与早期免疫反应之间的联系，我们在正常和狼疮易感小鼠品系中检测了DC和淋巴细胞亚群向dln的迁移以及IFN-I的作用。

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UV Light Exposure Induces a Type I Interferon Dependent Activation and Migration of Inflammatory Dendritic Cells to Local Lymph Nodes

Photosensitivity occurs in ~75% of lupus patients. Although ultraviolet light radiation (UVR) stimulates Type I interferon (IFN-I) in the skin, how UVR induced skin inflammation leads to downstream effects is poorly understood. Tissue inflammation causes DC to migrate from organs to draining lymph nodes (dLN) including a recently identified inflammatory DC subset (inf cDC2) that are potent antigen presenting cells. To explore links between UVR and the early immune response, we examined DC and lymphocyte subset migration to dLNs in normal and a lupus prone mouse strains as well as the role of IFN-I.

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来源期刊

Arthritis & Rheumatology RHEUMATOLOGY-

CiteScore

20.90

自引率

3.00%

发文量

371

期刊介绍： Arthritis & Rheumatology is the official journal of the American College of Rheumatology and focuses on the natural history, pathophysiology, treatment, and outcome of rheumatic diseases. It is a peer-reviewed publication that aims to provide the highest quality basic and clinical research in this field. The journal covers a wide range of investigative areas and also includes review articles, editorials, and educational material for researchers and clinicians. Being recognized as a leading research journal in rheumatology, Arthritis & Rheumatology serves the global community of rheumatology investigators and clinicians.