利用化学生物学揭示小分子的毒理学机制。

IF 3.7 3区医学 Q2 CHEMISTRY, MEDICINAL

Chemical Research in Toxicology Pub Date : 2025-01-20 Epub Date: 2025-01-11 DOI:10.1021/acs.chemrestox.4c00514

Anal Jana

引用次数: 0

摘要

确定各种小分子的潜在毒理学机制对于了解化学暴露相关人类疾病的发病机制和开发安全有效的治疗方法至关重要。在此，我们利用不同的化学生物学工具来讨论不同小分子的毒理学机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Revealing Toxicological Mechanisms of Small Molecules Using Chemical Biology.

Defining the underlying toxicological mechanisms of various small molecules is of utmost importance in understanding the pathogenesis of chemical exposure-related human diseases and developing safe and effective therapeutics. Herein, we discuss the toxicological mechanisms of different small molecules utilizing the different tools of chemical biology.

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来源期刊

Chemical Research in Toxicology 医学-毒理学

CiteScore

7.90

自引率

7.30%

发文量

215

审稿时长

3.5 months

期刊介绍： Chemical Research in Toxicology publishes Articles, Rapid Reports, Chemical Profiles, Reviews, Perspectives, Letters to the Editor, and ToxWatch on a wide range of topics in Toxicology that inform a chemical and molecular understanding and capacity to predict biological outcomes on the basis of structures and processes. The overarching goal of activities reported in the Journal are to provide knowledge and innovative approaches needed to promote intelligent solutions for human safety and ecosystem preservation. The journal emphasizes insight concerning mechanisms of toxicity over phenomenological observations. It upholds rigorous chemical, physical and mathematical standards for characterization and application of modern techniques.