使用体内系统在小鼠癌症模型中应用肿瘤治疗场的方案。

IF 1.3 Q4 BIOCHEMICAL RESEARCH METHODS

STAR Protocols Pub Date : 2025-01-08 DOI:10.1016/j.xpro.2024.103535

Travis J Gates, Sewar Zbidat, Karina Deniz, Sanyukta Padmanabhan, Katherine Ladner, Akshat Sarkari, Xianda Zhao, Shiri Davidi, Roni Blatt, Shay Cahal, Martin Gabay, Mariell Sellevoll, Itai Tzchori, Yaara Porat, Adi Haber, Moshe Giladi, Subbaya Subramanian, Emil Lou

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引用次数: 0

摘要

肿瘤治疗电场（TTFields）是临床批准用于癌症治疗的电场，通过附着在患者皮肤上的阵列输送。在这里，我们提出了一种使用体内系统将TTFields应用于躯干原位和皮下小鼠肿瘤模型的方案。我们指导用户正确的系统组件连接，研究方案设计，鼠标脱毛，阵列应用，治疗条件调整和监测。体内系统允许TTFields与标准癌症治疗同时应用。有关本协议使用和执行的完整细节，请参阅barshesheet等。

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Protocol for applying Tumor Treating Fields in mouse models of cancer using the inovivo system.

Tumor Treating Fields (TTFields) are electric fields clinically approved for cancer treatment, delivered via arrays attached to the patient's skin. Here, we present a protocol for applying TTFields to torso orthotopic and subcutaneous mouse tumor models using the inovivo system. We guide users on proper system component connections, study protocol design, mouse fur depilation, array application, and treatment condition adjustment and monitoring. The inovivo system allows for the concurrent application of TTFields with standard cancer therapies. For complete details on the use and execution of this protocol, please refer to Barsheshet et al.¹.

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