人脑嗅觉工作记忆的神经关联。

IF 4.7 2区医学 Q1 NEUROIMAGING

NeuroImage Pub Date : 2025-02-01 DOI:10.1016/j.neuroimage.2025.121005

Zhuofeng Li , Shu-bin Li , Shaozhen Tan , Lu-lu Liu , Chao Yan , Lai-quan Zou

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引用次数: 0

摘要

先前的研究表明，在气味记忆过程中，脑岛、苍白球、丘脑、海马体、额中回和补充运动区被激活，嗅觉工作记忆的表现受到气味言语化的影响。然而，嗅觉工作记忆的神经机制以及言语化在嗅觉工作记忆中的作用尚不完全清楚。29名参与者参加了一项研究，在接受功能磁共振成像的同时，使用高和低语言能力刺激完成嗅觉和视觉n-back任务。行为结果表明，参与者在视觉n-back任务中取得了比嗅觉n-back任务更高的准确性。我们观察到在嗅觉工作记忆过程中，中央前回、额上回、额中回、补充运动区和顶叶下回的激活增加。有趣的是，在嗅觉2-back任务中，与嗅觉0-back任务相比，激活程度有所降低。此外，在使用高可言语性气味的嗅觉工作记忆加工过程中，左角回和顶叶下回被更强烈地激活。综上所述，嗅觉工作记忆利用跨模态区域促进反应，参与工作记忆过程中信息的监控和操纵，具有不同于视觉工作记忆的独特激活模式。语义信息支持气味信息在工作记忆系统中的表征。

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Neural correlates of olfactory working memory in the human brain

Previous research has revealed that the insula, pallidum, thalamus, hippocampus, middle frontal gyrus, and supplementary motor area are activated during odor memory and that the performance of olfactory working memory is affected by the verbalization of odors. However, the neural mechanisms underlying olfactory working memory and the role of verbalization in olfactory working memory are not fully understood. Twenty-nine participants were enrolled in a study to complete olfactory and visual n-back tasks using high- and low-verbalizability stimuli while undergoing fMRI imaging. The behavioral results showed that the participants achieved greater accuracy in the visual rather than olfactory n-back task. We observed increased activation in the precentral gyrus, superior frontal gyrus, middle frontal gyrus, supplementary motor area, and inferior parietal gyrus during olfactory working memory. Interestingly, decreased activation was observed in the olfactory 2-back task versus the 0-back task. Moreover, the left angular gyrus and inferior parietal gyrus were more strongly activated during processing of olfactory working memory using high-verbalizability odors. In conclusion, olfactory working memory engages cross-modal regions to facilitate responses, is involved in the monitoring and manipulation of information during working memory, and boasts a unique activation pattern that is different from that of visual working memory. Semantic information supports the representation of odor information in the working memory system.

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来源期刊

NeuroImage 医学-核医学

CiteScore

11.30

自引率

10.50%

发文量

809

审稿时长

63 days

期刊介绍： NeuroImage, a Journal of Brain Function provides a vehicle for communicating important advances in acquiring, analyzing, and modelling neuroimaging data and in applying these techniques to the study of structure-function and brain-behavior relationships. Though the emphasis is on the macroscopic level of human brain organization, meso-and microscopic neuroimaging across all species will be considered if informative for understanding the aforementioned relationships.