Zoey A Lockwood, Michael R Jirousek, James P Basilion, Clemens Burda
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Applications of Au25 Nanoclusters in Photon-Based Cancer Therapies.
Atomically precise gold nanoclusters (AuNCs) exhibit unique physical and optical properties, making them highly promising for targeted cancer therapy. Their small size enhances cellular uptake, facilitates rapid distribution to tumor tissues, and minimizes accumulation in non-target organs compared to larger gold nanoparticles. AuNCs, particularly Au25, show significant potential in phototherapy, including photothermal (PTT), photodynamic (PDT), and radiation therapies. These therapies benefit with minimal damage to surrounding healthy tissue. AuNCs also demonstrate excellent stability and biocompatibility, crucial for their effective use in clinical applications. Recent advances in the synthesis and functionalization of AuNCs have further improved their therapeutic efficacy, making them versatile agents for enhancing cancer treatment outcomes. Ongoing research aims to better understand their pharmacokinetics, biodistribution, and long-term safety, paving the way for their broader application in advanced cancer therapies.
期刊介绍：
Nanomaterials (ISSN 2076-4991) is an international and interdisciplinary scholarly open access journal. It publishes reviews, regular research papers, communications, and short notes that are relevant to any field of study that involves nanomaterials, with respect to their science and application. Thus, theoretical and experimental articles will be accepted, along with articles that deal with the synthesis and use of nanomaterials. Articles that synthesize information from multiple fields, and which place discoveries within a broader context, will be preferred. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental or methodical details, or both, must be provided for research articles. Computed data or files regarding the full details of the experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material. Nanomaterials is dedicated to a high scientific standard. All manuscripts undergo a rigorous reviewing process and decisions are based on the recommendations of independent reviewers.
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