{"title":"CO2激光与米诺地尔治疗斑秃的比较研究。","authors":"Esraa Elsayed Elhawary, Naeim Mohamed Abdelnaby, Ghada Fawzy Rezk, Asmaa Mohamed Qandil","doi":"10.1002/lsm.23876","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Alopecia areata (AA) is a chronic inflammatory disease that affects the hair follicles and sometimes the nails. It usually presents as a single or multiple patches of hair loss on the scalp, but any hair-bearing skin can be involved. AA treatment depends on the severity and extent of the disease.</p>\n </section>\n \n <section>\n \n <h3> Objective</h3>\n \n <p>To evaluate the efficacy of combined fractional CO<sub>2</sub> (FCO<sub>2</sub>) laser with topical minoxidil 5% solution versus topical minoxidil 5% solution alone in the treatment of AA.</p>\n </section>\n \n <section>\n \n <h3> Patients and Methods</h3>\n \n <p>The study included 150 patients with AA. The patients were collected from outpatient clinics of the Dermatology and Venerology Department, Tanta University Hospitals. Patients were divided into three groups; 60 patients were treated with topical minoxidil 5% solution, 60 patients were treated with FCO<sub>2</sub> laser combined with topical minoxidil 5% solution, and the third group of 30 patients represented the control group treated with topical saline.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Compared to the placebo group, there was a statistically significant improvement in hair growth in the combination group and minoxidil group. In the combination group, 80% of patients showed excellent improvement, 13.3% of patients showed very good improvement, and 6.7% of patients showed good improvement. In the minoxidil group, 53% of patients showed excellent improvement, 40% of patients showed very good improvement, and 6.7% of patients showed good improvement after 3 months of therapy. Side effects were minimal and transient in both groups.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Topical minoxidil 5% solution either alone or in combination with FCO<sub>2</sub> laser could be considered a safe and tolerable method for AA treatment.</p>\n </section>\n </div>","PeriodicalId":17961,"journal":{"name":"Lasers in Surgery and Medicine","volume":"57 2","pages":"154-162"},"PeriodicalIF":2.2000,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Fractional CO2 Laser and Minoxidil in the Treatment of Alopecia Areata, A Comparative Study\",\"authors\":\"Esraa Elsayed Elhawary, Naeim Mohamed Abdelnaby, Ghada Fawzy Rezk, Asmaa Mohamed Qandil\",\"doi\":\"10.1002/lsm.23876\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Alopecia areata (AA) is a chronic inflammatory disease that affects the hair follicles and sometimes the nails. It usually presents as a single or multiple patches of hair loss on the scalp, but any hair-bearing skin can be involved. AA treatment depends on the severity and extent of the disease.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>To evaluate the efficacy of combined fractional CO<sub>2</sub> (FCO<sub>2</sub>) laser with topical minoxidil 5% solution versus topical minoxidil 5% solution alone in the treatment of AA.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Patients and Methods</h3>\\n \\n <p>The study included 150 patients with AA. The patients were collected from outpatient clinics of the Dermatology and Venerology Department, Tanta University Hospitals. Patients were divided into three groups; 60 patients were treated with topical minoxidil 5% solution, 60 patients were treated with FCO<sub>2</sub> laser combined with topical minoxidil 5% solution, and the third group of 30 patients represented the control group treated with topical saline.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Compared to the placebo group, there was a statistically significant improvement in hair growth in the combination group and minoxidil group. In the combination group, 80% of patients showed excellent improvement, 13.3% of patients showed very good improvement, and 6.7% of patients showed good improvement. In the minoxidil group, 53% of patients showed excellent improvement, 40% of patients showed very good improvement, and 6.7% of patients showed good improvement after 3 months of therapy. Side effects were minimal and transient in both groups.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>Topical minoxidil 5% solution either alone or in combination with FCO<sub>2</sub> laser could be considered a safe and tolerable method for AA treatment.</p>\\n </section>\\n </div>\",\"PeriodicalId\":17961,\"journal\":{\"name\":\"Lasers in Surgery and Medicine\",\"volume\":\"57 2\",\"pages\":\"154-162\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-01-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Lasers in Surgery and Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/lsm.23876\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lasers in Surgery and Medicine","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/lsm.23876","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DERMATOLOGY","Score":null,"Total":0}
Fractional CO2 Laser and Minoxidil in the Treatment of Alopecia Areata, A Comparative Study
Background
Alopecia areata (AA) is a chronic inflammatory disease that affects the hair follicles and sometimes the nails. It usually presents as a single or multiple patches of hair loss on the scalp, but any hair-bearing skin can be involved. AA treatment depends on the severity and extent of the disease.
Objective
To evaluate the efficacy of combined fractional CO2 (FCO2) laser with topical minoxidil 5% solution versus topical minoxidil 5% solution alone in the treatment of AA.
Patients and Methods
The study included 150 patients with AA. The patients were collected from outpatient clinics of the Dermatology and Venerology Department, Tanta University Hospitals. Patients were divided into three groups; 60 patients were treated with topical minoxidil 5% solution, 60 patients were treated with FCO2 laser combined with topical minoxidil 5% solution, and the third group of 30 patients represented the control group treated with topical saline.
Results
Compared to the placebo group, there was a statistically significant improvement in hair growth in the combination group and minoxidil group. In the combination group, 80% of patients showed excellent improvement, 13.3% of patients showed very good improvement, and 6.7% of patients showed good improvement. In the minoxidil group, 53% of patients showed excellent improvement, 40% of patients showed very good improvement, and 6.7% of patients showed good improvement after 3 months of therapy. Side effects were minimal and transient in both groups.
Conclusion
Topical minoxidil 5% solution either alone or in combination with FCO2 laser could be considered a safe and tolerable method for AA treatment.
期刊介绍：
Lasers in Surgery and Medicine publishes the highest quality research and clinical manuscripts in areas relating to the use of lasers in medicine and biology. The journal publishes basic and clinical studies on the therapeutic and diagnostic use of lasers in all the surgical and medical specialties. Contributions regarding clinical trials, new therapeutic techniques or instrumentation, laser biophysics and bioengineering, photobiology and photochemistry, outcomes research, cost-effectiveness, and other aspects of biomedicine are welcome. Using a process of rigorous yet rapid review of submitted manuscripts, findings of high scientific and medical interest are published with a minimum delay.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
