中性粒细胞胞外陷阱(NETs)作为抗衰老的潜在靶点:治疗性分离的作用。

IF 1.8 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Natalia Jarzebska, Roman N Rodionov, Karin Voit-Bak, Richard Straube, Anna Mücke, Sergey Tselmin, Ronny Rettig, Ulrich Julius, Richard Siow, Jürgen Gräßler, Jens Passauer, Yannick Kok, Philip Mavberg, Norbert Weiss, Stefan R Bornstein, Andrew Aswani
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引用次数: 0

摘要

中性粒细胞胞外陷阱(NETs)是由中性粒细胞在细胞外释放的染色质、组蛋白和颗粒衍生蛋白组成的大型结构。它们通常被认为是抗微生物防御策略的一部分,可以防止病原体的传播。然而,net的过量产生或其无效清除可导致各种病理,其中许多与老年有关,并涉及不受控制的炎症、氧化、心血管和神经退行性应激作为潜在机制。针对老年人的NETs作为一种抗衰老疗法似乎是一种非常有吸引力的治疗方法。使用特定过滤器去除NETs的治疗性分离可能是一种值得考虑的有前途的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neutrophil Extracellular Traps (NETs) as a Potential Target for Anti-Aging: Role of Therapeutic Apheresis.

Neutrophil extracellular traps (NETs) are large structures composed of chromatin, histones and granule-derived proteins released extracellularly by neutrophils. They are generally considered to be a part of the antimicrobial defense strategy, preventing the dissemination of pathogens. However, overproduction of NETs or their ineffective clearance can drive various pathologies, many of which are associated with advanced age and involve uncontrolled inflammation, oxidative, cardiovascular and neurodegenerative stress as underlying mechanisms. Targeting NETs in the elderly as an anti-aging therapy seems to be a very attractive therapeutic approach. Therapeutic apheresis with a specific filter to remove NETs could be a promising strategy worth considering.

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来源期刊
Hormone and Metabolic Research
Hormone and Metabolic Research 医学-内分泌学与代谢
CiteScore
3.80
自引率
0.00%
发文量
125
审稿时长
3-8 weeks
期刊介绍: Covering the fields of endocrinology and metabolism from both, a clinical and basic science perspective, this well regarded journal publishes original articles, and short communications on cutting edge topics. Speedy publication time is given high priority, ensuring that endocrinologists worldwide get timely, fast-breaking information as it happens. Hormone and Metabolic Research presents reviews, original papers, and short communications, and includes a section on Innovative Methods. With a preference for experimental over observational studies, this journal disseminates new and reliable experimental data from across the field of endocrinology and metabolism to researchers, scientists and doctors world-wide.
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