99mTc-FAPI-46成像在甲状腺髓样癌患者中的应用：导航新型放射性示踪剂的前景。

IF 9.6 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical Nuclear Medicine Pub Date : 2025-04-01 Epub Date: 2024-12-31 DOI:10.1097/RLU.0000000000005605

Nasrin Raeisi, Amin Saber Tanha, Somayeh Barashki, Navid Nateghi, Kamran Aryana

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引用次数: 0

摘要

摘要：我们报告一例58岁男性转移性甲状腺髓样癌，常规治疗包括肽受体放射性核素治疗无效。尽管多次干预，血清降钙素和癌胚抗原水平继续上升。随后99mTc-FAPI-46的评估显示转移灶中有明显的摄取，表明fapi标记的放射性同位素在甲状腺髓样癌的治疗中具有潜在的作用。该病例强调了fapi靶向放射性示踪剂在肿瘤核医学中的新兴应用，并强调了在这一有前途的领域进一步研究的必要性。

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Application of 99m Tc-FAPI-46 Imaging in a Patient With Medullary Thyroid Carcinoma : Navigating the Landscape of Novel Radiotracers.

Abstract: We present the case of a 58-year-old man with metastatic medullary thyroid carcinoma refractory to conventional therapies, including peptide receptor radionuclide therapy. Despite multiple interventions, serum calcitonin and carcinoembryonic antigen levels continued to rise. Subsequent evaluation with 99m Tc-FAPI-46 revealed remarkable uptake in metastatic lesions, suggesting a potential role for FAPI-labeled radioisotopes in the management of medullary thyroid carcinoma. This case underscores the emerging utility of FAPI-targeted radiotracers in oncologic nuclear medicine and highlights the need for further research in this promising area.

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来源期刊

Clinical Nuclear Medicine 医学-核医学

CiteScore

2.90

自引率

31.10%

发文量

1113

审稿时长

2 months

期刊介绍： Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.