植物化合物作为基孔肯雅病毒非结构蛋白2蛋白酶拮抗剂的研究进展

IF 6.7 1区医学 Q1 CHEMISTRY, MEDICINAL

Phytomedicine Pub Date : 2025-01-01 DOI:10.1016/j.phymed.2024.156359

Jarmani Dansana, Priyanka Purohit, Madhusmita Panda, Biswa Ranjan Meher

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引用次数: 0

摘要

背景：被称为基孔肯雅病毒（CHIKV）的蚊媒致病性甲病毒正在成为对公共卫生的更大危害，每年在全世界许多不同国家的农村和城市地区造成数千例病例。寻找和创造关于CHIKV病毒的新线索至关重要，因为目前还没有针对它的有效药物或疫苗。非结构蛋白2 （nsP2）蛋白酶由于其在病毒复制中的关键作用而成为治疗干预的一个有希望的靶点。目的：本系统综述旨在评价天然产物作为CHIKV nsP2蛋白酶抑制剂的最新进展，总结目前的研究，确定有前途的化合物，并强调现有知识的空白。研究设计：在2006年1月至2024年6月期间，使用PubMed、Scopus、Science Direct和谷歌Scholar等数据库进行了全面的文献检索。搜索词包括CHIKV、nsP2蛋白酶、抗病毒药物、天然产物、植物化学物质和抑制剂。研究是根据预先确定的纳入和排除标准选择的，重点是研究天然产物作为CHIKV nsP2蛋白酶抑制剂的原始研究文章。方法：筛选相关研究，提取天然化合物来源、提取方法、化学结构、作用机制、效力、抑制nsP2蛋白酶或CHIKV复制的功效等数据。结果：回顾了40项研究，揭示了多种天然产物及其衍生物对CHIKV nsP2蛋白酶具有抑制作用。几种化合物显示出良好的抑制活性，EC50值在微摩尔范围内。机制研究揭示了多种作用模式，包括抑制蛋白酶活性或干扰病毒复制过程。结论：天然产物因其丰富的化学结构和生物活性而受到人们的关注，提供了丰富的抗病毒化合物来源。我们总结了目前已知的各种来源的天然产物，包括黄酮类、生物碱、萜类、多酚类和一些衍生物，它们通过不同的作用机制显示出对CHIKV的抑制作用。总的来说，本系统综述强调了探索天然产物作为开发有效治疗基孔肯雅热的有希望的候选药物的重要性，特别是通过靶向nsP2蛋白酶。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Recent advances in phytocompounds as potential Chikungunya virus non-structural protein 2 protease antagonists: A systematic review

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Recent advances in phytocompounds as potential Chikungunya virus non-structural protein 2 protease antagonists: A systematic review

Background

The mosquito-borne pathogenic alphavirus known as Chikungunya virus (CHIKV) is becoming a greater hazard to public health, which causes thousands of cases annually in both rural and urban areas of many different nations throughout the world. Finding and creating new leads for the CHIKV virus is crucial because there are currently no effective medications or vaccinations against it. The non-structural protein 2 (nsP2) protease has emerged as a promising target for therapeutic intervention due to its crucial role in viral replication.

Purpose

This systematic review aims to evaluate recent advances in natural products as inhibitors of the CHIKV nsP2 protease, summarizing current research, identifying promising compounds, and highlighting gaps in the existing knowledge.

Study design

A comprehensive literature search was conducted between January 2006, and June 2024 using databases including PubMed, Scopus, Science Direct, and Google Scholar. Search terms included CHIKV, nsP2 protease, antivirals, natural products, phytochemicals, and inhibitors. Studies were selected based on predefined inclusion and exclusion criteria, focusing on original research articles examining natural products as inhibitors of CHIKV nsP2 protease.

Methods

Relevant studies were screened, and data were extracted regarding the source of natural compounds, methods of extraction, chemical structures, mechanisms of action, potency, and efficacy in inhibiting nsP2 protease or CHIKV replication.

Results

The review included 40 studies, revealing a variety of natural products and their derivatives with inhibitory effects on CHIKV nsP2 protease. Several compounds demonstrated promising inhibitory activity with EC50 values in the micromolar range. Mechanistic studies revealed diverse modes of action, including inhibition of protease activity or interference with viral replication processes.

Conclusion

Natural products have gained attention for their diverse chemical structures and bioactivities, offering a rich source of compounds with antiviral potential. We summarize the current knowledge on natural products derived from various sources including flavonoids, alkaloids, terpenoids, polyphenols, and some derivative compounds that have demonstrated inhibitory effects against CHIKV through different mechanisms of action. Overall, this systematic review underscores the importance of exploring natural products as promising candidates for the development of effective therapeutics against Chikungunya fever, particularly through targeting the nsP2 protease.

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来源期刊

Phytomedicine 医学-药学

CiteScore

10.30

自引率

5.10%

发文量

670

审稿时长

91 days

期刊介绍： Phytomedicine is a therapy-oriented journal that publishes innovative studies on the efficacy, safety, quality, and mechanisms of action of specified plant extracts, phytopharmaceuticals, and their isolated constituents. This includes clinical, pharmacological, pharmacokinetic, and toxicological studies of herbal medicinal products, preparations, and purified compounds with defined and consistent quality, ensuring reproducible pharmacological activity. Founded in 1994, Phytomedicine aims to focus and stimulate research in this field and establish internationally accepted scientific standards for pharmacological studies, proof of clinical efficacy, and safety of phytomedicines.