如何设计吸入式药物：CHF-6523

IF 6.8 1区医学 Q1 CHEMISTRY, MEDICINAL

Journal of Medicinal Chemistry Pub Date : 2025-01-06 DOI:10.1021/acs.jmedchem.4c03130

Matthew W. D. Perry

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引用次数: 0

摘要

吸入疗法提供了将药物靶向作用于肺部的机会，有可能提高治疗呼吸系统疾病的疗效和安全性。吸入药物的发现是一项专业工作，与口服药物的药物化学研究面临着不同的挑战。因此，一个成功的吸入式 PI3Kδ 抑制剂研究项目的出现，为我们提供了一个机会，借以强调一个团队如何应对在确定此类化合物时所面临的挑战。本视点旨在重点介绍吸入领域药物化学的一个典范。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

How to Design an Inhaled Drug: CHF-6523

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How to Design an Inhaled Drug: CHF-6523

Inhalation provides an opportunity to target drugs to the lung, potentially improving efficacy and safety margins for the treatment of respiratory conditions. The discovery of inhaled medicines is a specialized endeavor and has different challenges to medicinal chemistry for oral drugs. The appearance of a successful campaign delivering an inhaled PI3Kδ inhibitor is therefore an opportunity to highlight how a team can address the challenges involved in the identification of such a compound. This Viewpoint seeks to highlight a great example of medicinal chemistry in the inhaled space.

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来源期刊

Journal of Medicinal Chemistry 医学-医药化学

CiteScore

4.00

自引率

11.00%

发文量

804

审稿时长

1.9 months

期刊介绍： The Journal of Medicinal Chemistry is a prestigious biweekly peer-reviewed publication that focuses on the multifaceted field of medicinal chemistry. Since its inception in 1959 as the Journal of Medicinal and Pharmaceutical Chemistry, it has evolved to become a cornerstone in the dissemination of research findings related to the design, synthesis, and development of therapeutic agents. The Journal of Medicinal Chemistry is recognized for its significant impact in the scientific community, as evidenced by its 2022 impact factor of 7.3. This metric reflects the journal's influence and the importance of its content in shaping the future of drug discovery and development. The journal serves as a vital resource for chemists, pharmacologists, and other researchers interested in the molecular mechanisms of drug action and the optimization of therapeutic compounds.