壳聚糖基纳米凝胶在肿瘤纳米医学中的应用。

IF 2.6 4区医学 Q2 PHARMACOLOGY & PHARMACY

Current pharmaceutical design Pub Date : 2025-01-01 DOI:10.2174/0113816128347060241105032329

Yue Wang, Xiaoli Lou, Liyuan Yang, Yanqiang Hou

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引用次数: 0

摘要

壳聚糖是一种天然材料，在抗菌、抗氧化、螯合等方面具有许多独特的物理化学和生物特性。近年来，壳聚糖基纳米凝胶（CS-NG）因其具有生物可降解性、生物相容性、柔韧性、大表面积、可控性、高负载能力等优良特性，特别是其可被设计成对肿瘤环境具有刺激响应性，在肿瘤纳米医学领域得到了广泛的应用。本文综述了CS-NGs的主要合成方法，包括自由基聚合法、自组装法、微乳液法和离子凝胶法。这些新型的CS-NGs被应用于癌症纳米医学中，作为药物传递、基因传递和生物成像。此外，我们对CS-NGs肿瘤纳米医学应用的临床发展提出了展望。

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Application of Chitosan-based Nanogel in Cancer Nanomedicine.

Chitosan is a kind of natural material with many unique physicochemical and biological properties related to antibacterial, antioxidant, and chelating. In recent years, chitosan-based nano gels (CS-NG) have been widely used in the field of cancer nanomedicine due to their excellent characteristics including biodegradability, biocompatibility, flexibility, large surface area, controllability, high loading capacity, and especially it can be engineered to become stimuli-responsive to tumor environments. In this review, we summarized the main synthesis approaches of CS-NGs including radical polymerization, self-assembly, microemulsion, and ionic gelation methods. These novel CS-NGs are applied in cancer nanomedicine serving as drug delivery, gene delivery, and bioimaging. Besides, we proposed our perspectives regarding the clinical development of CS-NGs cancer nanomedicine applications.

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来源期刊

Current pharmaceutical design 医学-药学

CiteScore

6.30

自引率

0.00%

发文量

302

审稿时长

2 months

期刊介绍： Current Pharmaceutical Design publishes timely in-depth reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field. Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.