Ugiloy Yu. Yusupova, Khayrulla M. Bobakulov, Alisher R. Khurramov, Vladimir N. Syrov, Feruza R. Egamova, Anas Karuth, Durbek A. Usmanov, Mohiuddin Quadir, Bakhtiyor Rasulev
{"title":"牡丹的植物化学成分分离","authors":"Ugiloy Yu. Yusupova, Khayrulla M. Bobakulov, Alisher R. Khurramov, Vladimir N. Syrov, Feruza R. Egamova, Anas Karuth, Durbek A. Usmanov, Mohiuddin Quadir, Bakhtiyor Rasulev","doi":"10.1007/s00044-024-03345-6","DOIUrl":null,"url":null,"abstract":"<div><p>In this work, with the aim to find new and biologically active natural compounds, the chemical content of the apolar and polar extracts (aerial part) of <i>Silene popovii</i> has been investigated. The obtained extracts of <i>Silene popovii</i> Schischk were purified by column chromatography (CC), and four compounds were isolated: one of them is a new saponin compound—silepovin (<b>1</b>), as well as three known secondary metabolites, 2-deoxy-α-ecdysone (<b>2</b>), cauloside A (<b>3</b>) and 20-hydroxyecdysone 22-benzoate (<b>4</b>). The structural elucidation of isolated compounds was performed using the 1D and 2D NMR spectroscopy analyses and LC-MS analysis, and all four structures were confirmed. For the new compound <b>1</b>, an in vivo study of anti-inflammatory activity was conducted. The in vivo analysis has shown significant anti-inflammatory effects.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":699,"journal":{"name":"Medicinal Chemistry Research","volume":"34 2","pages":"423 - 431"},"PeriodicalIF":2.6000,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Phytochemical constituents isolated from Silene popovii Schischk\",\"authors\":\"Ugiloy Yu. Yusupova, Khayrulla M. Bobakulov, Alisher R. Khurramov, Vladimir N. Syrov, Feruza R. Egamova, Anas Karuth, Durbek A. Usmanov, Mohiuddin Quadir, Bakhtiyor Rasulev\",\"doi\":\"10.1007/s00044-024-03345-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In this work, with the aim to find new and biologically active natural compounds, the chemical content of the apolar and polar extracts (aerial part) of <i>Silene popovii</i> has been investigated. The obtained extracts of <i>Silene popovii</i> Schischk were purified by column chromatography (CC), and four compounds were isolated: one of them is a new saponin compound—silepovin (<b>1</b>), as well as three known secondary metabolites, 2-deoxy-α-ecdysone (<b>2</b>), cauloside A (<b>3</b>) and 20-hydroxyecdysone 22-benzoate (<b>4</b>). The structural elucidation of isolated compounds was performed using the 1D and 2D NMR spectroscopy analyses and LC-MS analysis, and all four structures were confirmed. For the new compound <b>1</b>, an in vivo study of anti-inflammatory activity was conducted. The in vivo analysis has shown significant anti-inflammatory effects.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":699,\"journal\":{\"name\":\"Medicinal Chemistry Research\",\"volume\":\"34 2\",\"pages\":\"423 - 431\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2024-11-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medicinal Chemistry Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s00044-024-03345-6\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicinal Chemistry Research","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s00044-024-03345-6","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Phytochemical constituents isolated from Silene popovii Schischk
In this work, with the aim to find new and biologically active natural compounds, the chemical content of the apolar and polar extracts (aerial part) of Silene popovii has been investigated. The obtained extracts of Silene popovii Schischk were purified by column chromatography (CC), and four compounds were isolated: one of them is a new saponin compound—silepovin (1), as well as three known secondary metabolites, 2-deoxy-α-ecdysone (2), cauloside A (3) and 20-hydroxyecdysone 22-benzoate (4). The structural elucidation of isolated compounds was performed using the 1D and 2D NMR spectroscopy analyses and LC-MS analysis, and all four structures were confirmed. For the new compound 1, an in vivo study of anti-inflammatory activity was conducted. The in vivo analysis has shown significant anti-inflammatory effects.
期刊介绍：
Medicinal Chemistry Research (MCRE) publishes papers on a wide range of topics, favoring research with significant, new, and up-to-date information. Although the journal has a demanding peer review process, MCRE still boasts rapid publication, due in part, to the length of the submissions. The journal publishes significant research on various topics, many of which emphasize the structure-activity relationships of molecular biology.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
