Lindsay M Forbes, Natalie Bauer, Aritra Bhadra, Harm J Bogaard, Gaurav Choudhary, Kara N Goss, Stefan Gräf, Gustavo A Heresi, Rachel K Hopper, Arun Jose, Yunhye Kim, Timothy Klouda, Tim Lahm, Allan Lawrie, Peter J Leary, Jane A Leopold, Suellen D Oliveira, Sasha Z Prisco, Ruslan Rafikov, Christopher J Rhodes, Duncan J Stewart, Rebecca R Vanderpool, Ke Yuan, Alexsandra Zimmer, Anna R Hemnes, Vinicio A de Jesus Perez, Martin R Wilkins
{"title":"肺血管疾病的精准医学：未来就是现在（2023 Grover会议系列）。","authors":"Lindsay M Forbes, Natalie Bauer, Aritra Bhadra, Harm J Bogaard, Gaurav Choudhary, Kara N Goss, Stefan Gräf, Gustavo A Heresi, Rachel K Hopper, Arun Jose, Yunhye Kim, Timothy Klouda, Tim Lahm, Allan Lawrie, Peter J Leary, Jane A Leopold, Suellen D Oliveira, Sasha Z Prisco, Ruslan Rafikov, Christopher J Rhodes, Duncan J Stewart, Rebecca R Vanderpool, Ke Yuan, Alexsandra Zimmer, Anna R Hemnes, Vinicio A de Jesus Perez, Martin R Wilkins","doi":"10.1002/pul2.70027","DOIUrl":null,"url":null,"abstract":"<p><p>Pulmonary vascular disease is not a single condition; rather it can accompany a variety of pathologies that impact the pulmonary vasculature. Applying precision medicine strategies to better phenotype, diagnose, monitor, and treat pulmonary vascular disease is increasingly possible with the growing accessibility of powerful clinical and research tools. Nevertheless, challenges exist in implementing these tools to optimal effect. The 2023 Grover Conference Series reviewed the research landscape to summarize the current state of the art and provide a better understanding of the application of precision medicine to managing pulmonary vascular disease. In particular, the following aspects were discussed: (1) Clinical phenotypes, (2) genetics, (3) epigenetics, (4) biomarker discovery, (5) application of precision biology to clinical trials, (6) the right ventricle (RV), and (7) integrating precision medicine to clinical care. The present review summarizes the content of these discussions and the prospects for the future.</p>","PeriodicalId":20927,"journal":{"name":"Pulmonary Circulation","volume":"15 1","pages":"e70027"},"PeriodicalIF":2.2000,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693987/pdf/","citationCount":"0","resultStr":"{\"title\":\"Precision Medicine for Pulmonary Vascular Disease: The Future Is Now (2023 Grover Conference Series).\",\"authors\":\"Lindsay M Forbes, Natalie Bauer, Aritra Bhadra, Harm J Bogaard, Gaurav Choudhary, Kara N Goss, Stefan Gräf, Gustavo A Heresi, Rachel K Hopper, Arun Jose, Yunhye Kim, Timothy Klouda, Tim Lahm, Allan Lawrie, Peter J Leary, Jane A Leopold, Suellen D Oliveira, Sasha Z Prisco, Ruslan Rafikov, Christopher J Rhodes, Duncan J Stewart, Rebecca R Vanderpool, Ke Yuan, Alexsandra Zimmer, Anna R Hemnes, Vinicio A de Jesus Perez, Martin R Wilkins\",\"doi\":\"10.1002/pul2.70027\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Pulmonary vascular disease is not a single condition; rather it can accompany a variety of pathologies that impact the pulmonary vasculature. Applying precision medicine strategies to better phenotype, diagnose, monitor, and treat pulmonary vascular disease is increasingly possible with the growing accessibility of powerful clinical and research tools. Nevertheless, challenges exist in implementing these tools to optimal effect. The 2023 Grover Conference Series reviewed the research landscape to summarize the current state of the art and provide a better understanding of the application of precision medicine to managing pulmonary vascular disease. In particular, the following aspects were discussed: (1) Clinical phenotypes, (2) genetics, (3) epigenetics, (4) biomarker discovery, (5) application of precision biology to clinical trials, (6) the right ventricle (RV), and (7) integrating precision medicine to clinical care. The present review summarizes the content of these discussions and the prospects for the future.</p>\",\"PeriodicalId\":20927,\"journal\":{\"name\":\"Pulmonary Circulation\",\"volume\":\"15 1\",\"pages\":\"e70027\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-01-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693987/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pulmonary Circulation\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/pul2.70027\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pulmonary Circulation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/pul2.70027","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Precision Medicine for Pulmonary Vascular Disease: The Future Is Now (2023 Grover Conference Series).
Pulmonary vascular disease is not a single condition; rather it can accompany a variety of pathologies that impact the pulmonary vasculature. Applying precision medicine strategies to better phenotype, diagnose, monitor, and treat pulmonary vascular disease is increasingly possible with the growing accessibility of powerful clinical and research tools. Nevertheless, challenges exist in implementing these tools to optimal effect. The 2023 Grover Conference Series reviewed the research landscape to summarize the current state of the art and provide a better understanding of the application of precision medicine to managing pulmonary vascular disease. In particular, the following aspects were discussed: (1) Clinical phenotypes, (2) genetics, (3) epigenetics, (4) biomarker discovery, (5) application of precision biology to clinical trials, (6) the right ventricle (RV), and (7) integrating precision medicine to clinical care. The present review summarizes the content of these discussions and the prospects for the future.
期刊介绍：
Pulmonary Circulation''s main goal is to encourage basic, translational, and clinical research by investigators, physician-scientists, and clinicans, in the hope of increasing survival rates for pulmonary hypertension and other pulmonary vascular diseases worldwide, and developing new therapeutic approaches for the diseases. Freely available online, Pulmonary Circulation allows diverse knowledge of research, techniques, and case studies to reach a wide readership of specialists in order to improve patient care and treatment outcomes.
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