高血压强化治疗对心血管事件的影响,适用于美国中老年高血压患者。

IF 5 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Nicola M Shen, Amal A Wanigatunga, Erin D Michos, Walter T Ambrosius, Catherine R Lesko
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引用次数: 0

摘要

收缩压干预试验(SPRINT)评估了强化收缩压治疗的效果
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Effect of Intensive Treatment of Hypertension on Cardiovascular Events, Generalized to Middle-Aged to Older Americans Living with Hypertension.

The Systolic Blood Pressure Intervention Trial (SPRINT) estimated the effect of intensive SBP treatment (target <120 mmHg) compared to standard (<140 mmHg) on the risk of cardiovascular events in adults aged 50+ years. Clinical trial participants may differ from an intervention's target population. We generalized the SPRINT results to U.S. adults who would qualify for treatment under SPRINT eligibility criteria. We applied these eligibility criteria to participants of the National Health and Nutrition Examination Survey (NHANES) in 2011 - 2018 to describe the target population. We estimated Cox proportional hazards models and Kaplan-Meier risk curves, weighted with the inverse odds of sampling, to estimate hazards ratios (HR) and 5-year risk differences for the effect of intensive treatment on cardiovascular and adverse events in the target population. The HR for CVD events was 0.76 (0.53, 1.08) comparing intensive to standard treatment, which is consistent with the estimates from the original SPRINT trial. The 5-year risk difference for a cardiovascular event was -2.2% (-5.3%, 1.6%). The HR for serious adverse events was 0.97 (0.83, 1.13). Despite differences between the SPRINT and target populations, we estimated a similar benefit of intensive treatment and similar rates of SAEs, in the target population.

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来源期刊
American journal of epidemiology
American journal of epidemiology 医学-公共卫生、环境卫生与职业卫生
CiteScore
7.40
自引率
4.00%
发文量
221
审稿时长
3-6 weeks
期刊介绍: The American Journal of Epidemiology is the oldest and one of the premier epidemiologic journals devoted to the publication of empirical research findings, opinion pieces, and methodological developments in the field of epidemiologic research. It is a peer-reviewed journal aimed at both fellow epidemiologists and those who use epidemiologic data, including public health workers and clinicians.
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