环状rna在SARS-CoV-2发病机制中的作用：潜在的诊断生物标志物和治疗靶点

IF 3.9 4区生物学 Q1 GENETICS & HEREDITY

Functional & Integrative Genomics Pub Date : 2025-01-02 DOI:10.1007/s10142-024-01509-6

JiaJie Wu, Lele Li, Wei Xu, Xiaoping Xia, Yingping Wu

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引用次数: 0

摘要

自2019年12月以来，一种新型冠状病毒的全球传播引发了一场引人注目的公共卫生危机，引起了政府和学术实体的极大兴趣和审查。大量的研究工作致力于探索这种新型冠状病毒的各个方面，包括其发病机制、传播动力学和治疗干预措施。最近的研究结果表明，环状rna （circRNAs）在调节病毒感染和免疫防御机制方面发挥着关键作用。在SARS-CoV-2患者中检测到差异表达的环状rna，标志着在理解病毒发病机制的分子机制方面取得了重大进展。

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Circular RNAs in the pathogenesis of SARS-CoV-2: potential diagnostic biomarkers and therapeutic targets

Since December 2019, the global dissemination of a novel coronavirus has precipitated a notable public health crisis, prompting considerable interest and scrutiny from governmental and scholarly entities. Substantial research efforts have been dedicated to exploring diverse facets of this novel coronavirus, encompassing its pathogenesis, transmission dynamics, and therapeutic interventions. Recent findings suggest that circular RNAs (circRNAs) exert a pivotal influence on modulating viral infectivity and immune defense mechanisms. The detection of differentially expressed circRNAs in individuals afflicted with SARS-CoV-2 signifies a noteworthy advancement in understanding the molecular mechanisms underpinning viral pathogenesis.

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来源期刊

Functional & Integrative Genomics 生物-遗传学

CiteScore

3.50

自引率

3.40%

发文量

审稿时长

2 months

期刊介绍： Functional & Integrative Genomics is devoted to large-scale studies of genomes and their functions, including systems analyses of biological processes. The journal will provide the research community an integrated platform where researchers can share, review and discuss their findings on important biological questions that will ultimately enable us to answer the fundamental question: How do genomes work?