染色质中心驱动白血病的关键调控网络

IF 14.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cell Pub Date : 2025-01-02 DOI:10.1016/j.molcel.2024.12.011

Alok Swaroop, Feng Yue

引用次数: 0

摘要

在本期的《分子细胞》杂志上，Gambi、Boccalatte、Hernaez等人应用多组学和基因工程技术来定义和表征对T-ALL至关重要的调控过程的表观遗传中心，并利用这一见解为靶向治疗提供新的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Chromatin hubs drive key regulatory networks in leukemia

In this issue of Molecular Cell, Gambi, Boccalatte, Hernaez, et al.¹ apply multiomics followed by genetic engineering to define then characterize epigenetic hubs that regulate processes crucial for T-ALL and use this insight to offer new avenues for therapeutic targeting.

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来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.