胶质母细胞瘤中的浆细胞和肿瘤干细胞串扰

IF 48.8 1区医学 Q1 CELL BIOLOGY

Cancer Cell Pub Date : 2025-01-02 DOI:10.1016/j.ccell.2024.12.007

Elijah Kirschstein, Andrew J. Gunderson

引用次数: 0

摘要

浆细胞（PCs）是抗体的主要产生者，在肿瘤免疫中具有环境依赖性作用。在这一期的Cancer Cell中，Gao等报道了肿瘤内的pc通过激活fc - γ riia - syk - akt信号轴的IgG分泌来驱动胶质母细胞瘤干细胞的维持，从而促进肿瘤的生长。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Plasma cell and cancer stem cell crosstalk in glioblastoma

Plasma cells (PCs) are the main producers of antibodies and have context-dependent roles in tumor immunity. In this issue of Cancer Cell, Gao et al. report that intratumoral PCs drive maintenance of glioblastoma stem cells to promote tumor growth via IgG secretion that activates a FcγRIIA-SYK-AKT signaling axis.

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.